7OT6

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND inhibitor RMC-282

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (C, A)	Reverse transcriptase/ribonuclease H	polymer	556	64022.4	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075)	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)	Exoribonuclease H,p66 RT
2	B, D (D, B)	Reverse transcriptase/ribonuclease H	polymer	428	50039.5	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815)	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)	Exoribonuclease H,p51 RT
3	E, H (E, T)	DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3')	polymer	27	8383.4	2		Human immunodeficiency virus type 1 BH10
4	F, G (F, P)	DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3')	polymer	20	6161.1	2		Homo sapiens
5	I (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	J (A)	(R)-N-(1-(6-amino-9H-purin-9-yl)propan-2-yl)-N-(2-phosphonoethyl)glycine	non-polymer		358.3	1	Chemie (1I4)

Sequence modifications

C, A: 1 - 554 (UniProt: P03366)

PDB	External Database	Details
Met -1	-	initiating methionine
Val 0	-	expression tag
Cys 258	Gln 857	conflict
Ser 280	Cys 879	conflict
Asn 498	Asp 1097	conflict

D, B: 1 - 428 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 879	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	257212.7
Non-Polymers*	Number of molecules	2
	Total formula weight	382.6
All*	Total formula weight	257595.3

*Water molecules are not included.