7OR9
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and COVOX-278 Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | E | Spike protein S1 | polymer | 205 | 23150.9 | 1 | UniProt (P0DTC2) Pfam (PF09408) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | RBD of S1 |
| 2 | A | COVOX-222 Fab heavy chain | polymer | 224 | 23461.2 | 1 | Homo sapiens | ||
| 3 | B | COVOX-222 Fab light chain | polymer | 214 | 23327.9 | 1 | Homo sapiens | ||
| 4 | H | COVOX-278 Fab heavy chain | polymer | 228 | 24362.4 | 1 | Homo sapiens | ||
| 5 | L | COVOX-278 Fab light chain | polymer | 215 | 23300.9 | 1 | Homo sapiens | ||
| 6 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 7 | E, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | E, A, B | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 9 | H | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 10 | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
E: 333 - 528 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Glu 324 | - | expression tag |
| Thr 325 | - | expression tag |
| Gly 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| Lys 527 | Pro 527 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 117603.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 520.2 | |
| All* | Total formula weight | 118693.9 |
