7OR9

Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and COVOX-278 Fabs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (E)	Spike protein S1	polymer	205	23150.9	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	RBD of S1
2	B (A)	COVOX-222 Fab heavy chain	polymer	224	23461.2	1		Homo sapiens
3	C (B)	COVOX-222 Fab light chain	polymer	214	23327.9	1		Homo sapiens
4	D (H)	COVOX-278 Fab heavy chain	polymer	228	24362.4	1		Homo sapiens
5	E (L)	COVOX-278 Fab light chain	polymer	215	23300.9	1		Homo sapiens
6	F (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
7	G, K (E, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
8	H, I, J, L (E, A, B)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
9	M (H)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
10	N, O, P, Q, R (E, A, B, H, L)	water	water		18.0	149	Chemie (HOH)

Sequence modifications

E: 333 - 528 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Lys 527	Pro 527	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	117603.2
Branched	Number of molecules	1
	Total formula weight	570.5
Non-Polymers*	Number of molecules	7
	Total formula weight	520.2
All*	Total formula weight	118693.9

*Water molecules are not included.