7OPP
Crystal structure of the Rab27a fusion with Slp2a-RBDa1 effector for SF4 pocket drug targeting
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Synaptotagmin-like protein 2,Ras-related protein Rab-27A | polymer | 230 | 25956.2 | 2 | UniProt (Q9HCH5) UniProt (P51159) Pfam (PF02318) Pfam (PF00071) In PDB | Homo sapiens (Human) | Breast cancer-associated antigen SGA-72M,Exophilin-4,Rab-27,GTP-binding protein Ram |
2 | A, C | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
3 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | water | water | 18.0 | 382 | Chemie (HOH) |
Sequence modifications
A, C: -35 - -8 (UniProt: Q9HCH5)
A, C: 1 - 192 (UniProt: P51159)
PDB | External Database | Details |
---|---|---|
His -37 | - | expression tag |
Met -36 | - | expression tag |
Asp -7 | - | linker |
Gly -6 | - | linker |
Ser -5 | - | linker |
Gly -4 | - | linker |
Ser -3 | - | linker |
Gly -2 | - | linker |
Ser -1 | - | linker |
Gly 0 | - | linker |
PDB | External Database | Details |
---|---|---|
Leu 78 | Gln 78 | engineered mutation |
Ser 123 | Cys 123 | engineered mutation |
Ser 188 | Cys 188 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 51912.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1093.0 | |
All* | Total formula weight | 53005.4 |