7OPG
Crystal structure of CLK1 in complex with compound 2 (CC513)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 3 | UniProt (P49759) Pfam (PF00069) In PDB | Homo sapiens (Human) | CDC-like kinase 1 |
| 2 | A, B, C | 4-[2-(propylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol | non-polymer | 274.3 | 3 | Chemie (06N) | |||
| 3 | A, B, C | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 4 | B, C | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | B | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 6 | water | water | 18.0 | 619 | Chemie (HOH) |
Sequence modifications
A, B, C: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 432 | Arg 432 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118744.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2172.2 | |
| All* | Total formula weight | 120916.7 |
