7OOW
Crystal structure of PIM1 in complex with ARC-1415
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase pim-1 | polymer | 313 | 35590.5 | 1 | UniProt (P11309) Pfam (PF00069) | Homo sapiens (human) | |
| 2 | B (B) | INHIBITOR ARC-1415 | polymer | 9 | 1314.6 | 1 | BIRD (PRD_002339) | synthetic construct | |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D, E, F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
A: 1 - 312 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Gly 250 | Arg 250 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36905.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 272.6 | |
| All* | Total formula weight | 37177.7 |
