7ONU

Structure of human mitochondrial RNase P in complex with mitochondrial pre-tRNA-Tyr

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	3-hydroxyacyl-CoA dehydrogenase type-2	polymer	261	26947.0	4	UniProt (Q99714) Pfam (PF00106) In PDB	Homo sapiens (Human)	17-beta-estradiol 17-dehydrogenase,2-methyl-3-hydroxybutyryl-CoA dehydrogenase,MHBD,3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)),3-hydroxy-2-methylbutyryl-CoA dehydrogenase,3-hydroxyacyl-CoA dehydrogenase type II,3alpha(or 20beta)-hydroxysteroid dehydrogenase,7-alpha-hydroxysteroid dehydrogenase,Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,Mitochondrial ribonuclease P protein 2,Mitochondrial RNase P protein 2,Short chain dehydrogenase/reductase family 5C member 1,Short-chain type dehydrogenase/reductase XH98G2,Type II HADH
2	E	Mitochondrial ribonuclease P catalytic subunit	polymer	541	62458.4	1	UniProt (O15091) Pfam (PF16953) In PDB	Homo sapiens (Human)	Mitochondrial ribonuclease P protein 3,Mitochondrial RNase P protein 3,Protein only RNase P catalytic subunit
3	F	tRNA methyltransferase 10 homolog C	polymer	367	42942.5	1	UniProt (Q7L0Y3) Pfam (PF01746) In PDB	Homo sapiens (Human)	HBV pre-S2 trans-regulated protein 2,Mitochondrial ribonuclease P protein 1,Mitochondrial RNase P protein 1,RNA (guanine-9-)-methyltransferase domain-containing protein 1,Renal carcinoma antigen NY-REN-49,mRNA methyladenosine-N(1)-methyltransferase,tRNA (adenine(9)-N(1))-methyltransferase,tRNA (guanine(9)-N(1))-methyltransferase
4	T	Mitochondrial Precursor tRNA-Tyr	polymer	128	41490.6	1		Homo sapiens (Human)
5	A, B, C, D	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
6	E	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
7	E	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

E: 46 - 583 (UniProt: O15091)

PDB	External Database	Details
Ser 43	-	expression tag
Asn 44	-	expression tag
Ala 45	-	expression tag

F: 40 - 403 (UniProt: Q7L0Y3)

PDB	External Database	Details
Ser 37	-	expression tag
Asn 38	-	expression tag
Ala 39	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	254679.5
Non-Polymers*	Number of molecules	6
	Total formula weight	2743.4
All*	Total formula weight	257423.0

*Water molecules are not included.