7OLS
MerTK kinase domain with type 1.5 inhibitor containing a di-methyl pyrazole group
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase Mer | polymer | 298 | 34381.8 | 1 | UniProt (Q12866) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK |
2 | A | 5-[4-(1,5-dimethylpyrazol-4-yl)-2-methyl-phenyl]-~{N}-(imidazo[1,2-a]pyridin-6-ylmethyl)-~{N}-methyl-1,3,4-oxadiazol-2-amine | non-polymer | 413.5 | 1 | Chemie (VJZ) | |||
3 | A | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
5 | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 571 - 864 (UniProt: Q12866)
PDB | External Database | Details |
---|---|---|
Gly 567 | - | expression tag |
Ser 568 | - | expression tag |
His 569 | - | expression tag |
Met 570 | - | expression tag |
Arg 591 | Lys 591 | engineered mutation |
Arg 693 | Lys 693 | engineered mutation |
Arg 702 | Lys 702 | engineered mutation |
Arg 856 | Lys 856 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34381.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 633.4 | |
All* | Total formula weight | 35015.2 |