7OG1

AP2 clathrin adaptor core in complex with cargo peptide and FCHO2

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAA	AP-2 complex subunit alpha-2	polymer	621	69656.3	1	UniProt (P18484) Pfam (PF01602) In PDB	Rattus norvegicus (Rat)	100 kDa coated vesicle protein C,Adaptor protein complex AP-2 subunit alpha-2,Adaptor-related protein complex 2 subunit alpha-2,Alpha-adaptin C,Alpha2-adaptin,Clathrin assembly protein complex 2 alpha-C large chain,Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
2	BBB	AP-2 complex subunit beta	polymer	591	66953.2	1	UniProt (P63010) Pfam (PF01602) In PDB	Homo sapiens (Human)	AP105B,Adaptor protein complex AP-2 subunit beta,Adaptor-related protein complex 2 subunit beta,Beta-2-adaptin,Beta-adaptin,Clathrin assembly protein complex 2 beta large chain,Plasma membrane adaptor HA2/AP2 adaptin beta subunit
3	MMM, CCC	AP-2 complex subunit mu	polymer	446	51044.1	2	UniProt (P84092) Pfam (PF01217) Pfam (PF00928) In PDB	Rattus norvegicus (Rat)	AP-2 mu chain,Adaptor protein complex AP-2 subunit mu,Adaptor-related protein complex 2 subunit mu,Clathrin assembly protein complex 2 mu medium chain,Clathrin coat assembly protein AP50,Clathrin coat-associated protein AP50,Mu2-adaptin,Plasma membrane adaptor AP-2 50 kDa protein
4	SSS	AP-2 complex subunit sigma	polymer	142	17038.7	1	UniProt (P62743) Pfam (PF01217) In PDB	Mus musculus (Mouse)	Adaptor protein complex AP-2 subunit sigma,Adaptor-related protein complex 2 subunit sigma,Clathrin assembly protein 2 sigma small chain,Clathrin coat assembly protein AP17,Clathrin coat-associated protein AP17,Plasma membrane adaptor AP-2 17 kDa protein,Sigma-adaptin 3b,Sigma2-adaptin
5	GGG, DDD	F-BAR domain only protein 2	polymer	152	17111.5	2	UniProt (Q0JRZ9) In PDB	Homo sapiens (Human)
6	PPP	TGN38 CARGO PEPTIDE	polymer	6	808.9	1		Homo sapiens

Sequence modifications

AAA: 1 - 621 (UniProt: P18484)

PDB	External Database	Details
Glu 272	-	insertion

MMM, CCC: 1 - 446 (UniProt: P84092)

PDB	External Database	Details
Met 237	-	insertion
Glu 238	-	insertion
Gln 239	-	insertion
Lys 240	-	insertion
Leu 241	-	insertion
Ile 242	-	insertion
Ser 243	-	insertion
Glu 244	-	insertion
Glu 245	-	insertion
Asp 246	-	insertion
Leu 247	-	insertion

GGG, DDD: 314 - 444 (UniProt: Q0JRZ9)

PDB	External Database	Details
Gly 309	-	expression tag
Ser 310	-	expression tag
Pro 311	-	expression tag
Glu 312	-	expression tag
Phe 313	-	expression tag
Glu 445	-	expression tag
Phe 446	-	expression tag
Pro 447	-	expression tag
Gly 448	-	expression tag
Arg 449	-	expression tag
Pro 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	290768.3
All*	Total formula weight	290768.3

*Water molecules are not included.