7OFK

Ligand complex of RORg LBD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Nuclear receptor ROR-gamma	polymer	266	30901.4	1	UniProt (P51449) Pfam (PF00104)	Homo sapiens (Human)	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma
2	B (C)	Nuclear receptor coactivator 2	polymer	16	1895.2	1	UniProt (Q15596)	Homo sapiens (Human)	NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2
3	C (A)	(1~{R})-2-ethanoyl-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]-5-methylsulfonyl-1,3-dihydroisoindole-1-carboxamide	non-polymer		524.4	1	Chemie (VCH)
4	D, E (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	2	Chemie (DMS)
5	F (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	G, H (A, C)	water	water		18.0	282	Chemie (HOH)

Sequence modifications

A: 265 - 507 (UniProt: P51449)

PDB	External Database	Details
His 244	-	expression tag
Asn 245	-	expression tag
His 246	-	expression tag
Asn 247	-	expression tag
His 248	-	expression tag
Asn 249	-	expression tag
His 250	-	expression tag
Asn 251	-	expression tag
His 252	-	expression tag
Asn 253	-	expression tag
His 254	-	expression tag
Asn 255	-	expression tag
Gly 256	-	expression tag
Gly 257	-	expression tag
Glu 258	-	expression tag
Asn 259	-	expression tag
Leu 260	-	expression tag
Tyr 261	-	expression tag
Phe 262	-	expression tag
Gln 263	-	expression tag
Gly 264	-	expression tag
Gly 508	-	expression tag
Gly 509	-	expression tag

C: 684 - 698 (UniProt: Q15596)

PDB	External Database	Details
Gly 683	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32796.6
Non-Polymers*	Number of molecules	4
	Total formula weight	703.7
All*	Total formula weight	33500.3

*Water molecules are not included.