7OEG
Crystal structure of the human METTL3-METTL14 complex with compound UOZ040b
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | N6-adenosine-methyltransferase catalytic subunit | polymer | 246 | 28144.1 | 1 | UniProt (Q86U44) Pfam (PF05063) In PDB | Homo sapiens (Human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
2 | B | N6-adenosine-methyltransferase non-catalytic subunit | polymer | 290 | 33621.2 | 1 | UniProt (Q9HCE5) Pfam (PF05063) In PDB | Homo sapiens (Human) | Methyltransferase-like protein 14,hMETTL14 |
3 | A | (R)-4-((2-azaspiro[3.3]heptan-2-yl)methyl)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)benzamide | non-polymer | 526.7 | 1 | Chemie (UEE) | |||
4 | B | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
5 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 354 - 580 (UniProt: Q86U44)
B: 107 - 395 (UniProt: Q9HCE5)
PDB | External Database | Details |
---|---|---|
Met 335 | - | initiating methionine |
Gly 336 | - | expression tag |
His 337 | - | expression tag |
His 338 | - | expression tag |
His 339 | - | expression tag |
His 340 | - | expression tag |
His 341 | - | expression tag |
His 342 | - | expression tag |
Ser 343 | - | expression tag |
Ser 344 | - | expression tag |
Gly 345 | - | expression tag |
Arg 346 | - | expression tag |
Glu 347 | - | expression tag |
Asn 348 | - | expression tag |
Leu 349 | - | expression tag |
Tyr 350 | - | expression tag |
Phe 351 | - | expression tag |
Gln 352 | - | expression tag |
Gly 353 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 106 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 61765.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 585.7 | |
All* | Total formula weight | 62351.0 |