7OCF
Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, C) | Isoform Flip of Glutamate receptor 1 | polymer | 915 | 102661.9 | 2 | UniProt (P19490) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1 |
| 2 | B, H (B, D) | Isoform Flip of Glutamate receptor 2 | polymer | 860 | 96247.1 | 2 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 3 | C, F (G, E) | Protein cornichon homolog 2 | polymer | 188 | 22000.6 | 2 | UniProt (Q5BJU5) Pfam (PF03311) | Rattus norvegicus (Rat) | CNIH-2,Cornichon family AMPA receptor auxiliary protein 2,Cornichon-like protein |
| 4 | D, G (I, J) | Voltage-dependent calcium channel gamma-8 subunit | polymer | 423 | 43576.0 | 2 | UniProt (Q8VHW5) Pfam (PF00822) | Rattus norvegicus (Rat) | Neuronal voltage-gated calcium channel gamma-8 subunit,Transmembrane AMPAR regulatory protein gamma-8,TARP gamma-8 |
| 5 | I, KA, Q, Z (A, D, B, C) | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) | |||
| 6 | AA, BA, CA, DA, EA... (C, E, J, A, D...) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 26 | Chemie (PC1) | |||
| 7 | GA, P, PA, W (C, A, D, B) | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) |
Sequence modifications
A, C: -25 - 889 (UniProt: P19490)
B, D: -20 - 839 (UniProt: P19491)
G, E: 1 - 160 (UniProt: Q5BJU5)
I, J: 2 - 417 (UniProt: Q8VHW5)
| PDB | External Database | Details |
|---|---|---|
| Asp -6 | - | insertion |
| Tyr -5 | - | insertion |
| Lys -4 | - | insertion |
| Asp -3 | - | insertion |
| Asp -2 | - | insertion |
| Asp -1 | - | insertion |
| Asp 0 | - | insertion |
| Lys 1 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Arg 586 | Gln 607 | variant |
| PDB | External Database | Details |
|---|---|---|
| Glu 161 | - | expression tag |
| Asn 162 | - | expression tag |
| Leu 163 | - | expression tag |
| Tyr 164 | - | expression tag |
| Phe 165 | - | expression tag |
| Gln 166 | - | expression tag |
| Ser 167 | - | expression tag |
| Gly 168 | - | expression tag |
| Gly 169 | - | expression tag |
| Ser 170 | - | expression tag |
| Thr 171 | - | expression tag |
| Glu 172 | - | expression tag |
| Thr 173 | - | expression tag |
| Ser 174 | - | expression tag |
| Gln 175 | - | expression tag |
| Val 176 | - | expression tag |
| Ala 177 | - | expression tag |
| Pro 178 | - | expression tag |
| Ala 179 | - | expression tag |
| Tyr 180 | - | expression tag |
| Pro 181 | - | expression tag |
| Tyr 182 | - | expression tag |
| Asp 183 | - | expression tag |
| Val 184 | - | expression tag |
| Pro 185 | - | expression tag |
| Asp 186 | - | expression tag |
| Tyr 187 | - | expression tag |
| Ala 188 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Leu 418 | - | expression tag |
| Glu 419 | - | expression tag |
| Val 420 | - | expression tag |
| Leu 421 | - | expression tag |
| Phe 422 | - | expression tag |
| Gln 423 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 528971.2 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 22691.8 | |
| All* | Total formula weight | 551663.0 |
