7OCA

Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, G (A, C)	Glutamate receptor 1	polymer	915	102661.9	2	UniProt (P19490) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1
2	B, E (B, D)	Glutamate receptor 2	polymer	860	96247.1	2	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
3	C, H (G, E)	Protein cornichon homolog 2	polymer	188	22000.6	2	UniProt (Q5BJU5) Pfam (PF03311)	Rattus norvegicus (Norway rat)	CNIH-2,Cornichon family AMPA receptor auxiliary protein 2,Cornichon-like protein
4	D, F (I, J)	Voltage-dependent calcium channel gamma-8 subunit	polymer	423	43576.0	2	UniProt (Q8VHW5) Pfam (PF00822)	Rattus norvegicus (Norway rat)	Neuronal voltage-gated calcium channel gamma-8 subunit,Transmembrane AMPAR regulatory protein gamma-8,TARP gamma-8
5	I, M (F, M)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
6	J, K, L, N (H, K, L, N)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
7	IB, O, RA, Y (C, A, D, B)	6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide	non-polymer		336.3	4	Chemie (E2Q)
8	JB, KB, P, Q, SA... (C, A, D, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
9	AA, AB, BA, BB, CA... (B, D, J, C, G...)	1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		790.1	46	Chemie (PC1)
10	KA, SB (G, E)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)

Sequence modifications

A, C: -25 - 889 (UniProt: P19490)

PDB	External Database	Details
Asp -6	-	insertion
Tyr -5	-	insertion
Lys -4	-	insertion
Asp -3	-	insertion
Asp -2	-	insertion
Asp -1	-	insertion
Asp 0	-	insertion
Lys 1	-	insertion

B, D: -20 - 839 (UniProt: P19491)

PDB	External Database	Details
Arg 586	Gln 607	conflict

G, E: 1 - 160 (UniProt: Q5BJU5)

PDB	External Database	Details
Glu 161	-	expression tag
Asn 162	-	expression tag
Leu 163	-	expression tag
Tyr 164	-	expression tag
Phe 165	-	expression tag
Gln 166	-	expression tag
Ser 167	-	expression tag
Gly 168	-	expression tag
Gly 169	-	expression tag
Ser 170	-	expression tag
Thr 171	-	expression tag
Glu 172	-	expression tag
Thr 173	-	expression tag
Ser 174	-	expression tag
Gln 175	-	expression tag
Val 176	-	expression tag
Ala 177	-	expression tag
Pro 178	-	expression tag
Ala 179	-	expression tag
Tyr 180	-	expression tag
Pro 181	-	expression tag
Tyr 182	-	expression tag
Asp 183	-	expression tag
Val 184	-	expression tag
Pro 185	-	expression tag
Asp 186	-	expression tag
Tyr 187	-	expression tag
Ala 188	-	expression tag

I, J: 2 - 417 (UniProt: Q8VHW5)

PDB	External Database	Details
Gly 1	-	expression tag
Leu 418	-	expression tag
Glu 419	-	expression tag
Val 420	-	expression tag
Leu 421	-	expression tag
Phe 422	-	expression tag
Gln 423	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	528971.2
Branched	Number of molecules	6
	Total formula weight	2870.7
Non-Polymers*	Number of molecules	58
	Total formula weight	39792.3
All*	Total formula weight	571634.2

*Water molecules are not included.