7OBT
Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide and stabilizer Fusicoccin-A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 253 | 28226.5 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (Human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (B) | Receptor-interacting serine/threonine-protein kinase 2 | polymer | 11 | 1325.4 | 1 | UniProt (O43353) | Homo sapiens | CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2 |
| 3 | C (A) | FUSICOCCIN | non-polymer | 680.8 | 1 | Chemie (FSC) PubChem (46936214) PubChem (24124005) PubChem (44201245) PubChem (52940549) PubChem (57061783) PubChem (58892803) PubChem (143471529) PubChem (89167108) PubChem (89358776) PubChem (270757) PubChem (71308204) PubChem (447573) PubChem (89352860) PubChem (89424149) PubChem (91305733) PubChem (5381214) PubChem (124914704) PubChem (124914702) PubChem (125183286) PubChem (6437071) PubChem (134693211) PubChem (12309993) PubChem (138107212) PubChem (11534864) PubChem (124914703) PubChem (124914705) PubChem (146157920) PubChem (163008024) PubChem (134688043) PubChem (163008025) PubChem (163728719) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 6 | G, H (A, B) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A: 1 - 248 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29552.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 764.9 | |
| All* | Total formula weight | 30316.9 |
