7OA9
Crystal structure of Human Menin in complex with Fragment 21
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2 of Menin | polymer | 505 | 56033.5 | 1 | UniProt (O00255) Pfam (PF05053) | Homo sapiens (Human) | |
| 2 | B (A) | (~{E})-2-cyano-3-(4-hydroxyphenyl)-~{N}-(2-morpholin-4-ylethyl)prop-2-enamide | non-polymer | 301.3 | 1 | Chemie (V6K) | |||
| 3 | C, E, F, G, H... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | K (A) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 1 - 584 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| Ala 0 | - | expression tag |
| - | Ile 54 | deletion |
| - | Pro 55 | deletion |
| - | Thr 56 | deletion |
| - | Asn 57 | deletion |
| - | Val 58 | deletion |
| - | Pro 59 | deletion |
| - | Glu 60 | deletion |
| - | Leu 61 | deletion |
| - | Thr 62 | deletion |
| - | Phe 63 | deletion |
| - | Gln 64 | deletion |
| - | Pro 65 | deletion |
| - | Ser 66 | deletion |
| - | Pro 67 | deletion |
| - | Ala 68 | deletion |
| - | Pro 69 | deletion |
| - | Asp 70 | deletion |
| - | Pro 71 | deletion |
| - | Pro 72 | deletion |
| - | Gly 73 | deletion |
| - | Arg 460 | deletion |
| - | Glu 461 | deletion |
| - | Ala 462 | deletion |
| - | Glu 463 | deletion |
| - | Ala 464 | deletion |
| - | Ala 465 | deletion |
| - | Glu 466 | deletion |
| - | Ala 467 | deletion |
| - | Glu 474 | deletion |
| - | Arg 476 | deletion |
| - | Glu 477 | deletion |
| - | Gly 478 | deletion |
| - | Arg 479 | deletion |
| - | Arg 480 | deletion |
| - | Arg 481 | deletion |
| - | Gly 482 | deletion |
| - | Pro 483 | deletion |
| - | Arg 484 | deletion |
| - | Arg 485 | deletion |
| - | Glu 486 | deletion |
| - | Ser 487 | deletion |
| - | Lys 488 | deletion |
| - | Pro 489 | deletion |
| - | Glu 490 | deletion |
| - | Glu 491 | deletion |
| - | Pro 492 | deletion |
| - | Pro 493 | deletion |
| - | Pro 494 | deletion |
| - | Pro 495 | deletion |
| - | Lys 496 | deletion |
| - | Lys 497 | deletion |
| - | Pro 498 | deletion |
| - | Ala 499 | deletion |
| - | Leu 500 | deletion |
| - | Asp 501 | deletion |
| - | Lys 502 | deletion |
| - | Gly 503 | deletion |
| - | Leu 504 | deletion |
| - | Gly 505 | deletion |
| - | Thr 506 | deletion |
| - | Gly 507 | deletion |
| - | Gln 508 | deletion |
| - | Gly 509 | deletion |
| - | Ala 510 | deletion |
| - | Val 511 | deletion |
| - | Ser 512 | deletion |
| - | Gly 513 | deletion |
| - | Pro 514 | deletion |
| - | Pro 515 | deletion |
| - | Arg 516 | deletion |
| - | Lys 517 | deletion |
| - | Pro 518 | deletion |
| - | Pro 519 | deletion |
| Ala 541 | Thr 541 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 56033.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 827.9 | |
| All* | Total formula weight | 56861.4 |
