7O9Z
Crystal structure of Human Menin in complex with BD-08
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Menin | polymer | 494 | 54833.3 | 1 | UniProt (A0A024R5E3) Pfam (PF05053) UniProt (by SIFTS) (O00255) In PDB | Homo sapiens (Human) | |
| 2 | A | (~{E})-2-cyano-3-(2~{H}-indazol-6-yl)-~{N}-(2-morpholin-4-ylethyl)prop-2-enamide | non-polymer | 325.4 | 1 | Chemie (V6N) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A: 1 - 584 (UniProt: A0A024R5E3)
| PDB | External Database | Details |
|---|---|---|
| Ala 0 | - | expression tag |
| - | Ile 54 | deletion |
| - | Pro 55 | deletion |
| - | Thr 56 | deletion |
| - | Asn 57 | deletion |
| - | Val 58 | deletion |
| - | Pro 59 | deletion |
| - | Glu 60 | deletion |
| - | Leu 61 | deletion |
| - | Thr 62 | deletion |
| - | Phe 63 | deletion |
| - | Gln 64 | deletion |
| - | Pro 65 | deletion |
| - | Ser 66 | deletion |
| - | Pro 67 | deletion |
| - | Ala 68 | deletion |
| - | Pro 69 | deletion |
| - | Asp 70 | deletion |
| - | Pro 71 | deletion |
| - | Pro 72 | deletion |
| - | Gly 73 | deletion |
| - | Glu 387 | deletion |
| - | Glu 388 | deletion |
| - | Arg 389 | deletion |
| - | Pro 390 | deletion |
| - | Gly 391 | deletion |
| - | Glu 392 | deletion |
| - | Gln 393 | deletion |
| - | Ser 394 | deletion |
| - | Gln 395 | deletion |
| - | Gly 396 | deletion |
| - | Thr 397 | deletion |
| - | Arg 460 | deletion |
| - | Glu 461 | deletion |
| - | Ala 462 | deletion |
| - | Glu 463 | deletion |
| - | Ala 464 | deletion |
| - | Ala 465 | deletion |
| - | Glu 466 | deletion |
| - | Ala 467 | deletion |
| - | Glu 468 | deletion |
| - | Glu 469 | deletion |
| - | Pro 470 | deletion |
| - | Trp 471 | deletion |
| - | Gly 472 | deletion |
| - | Glu 473 | deletion |
| - | Glu 474 | deletion |
| - | Ala 475 | deletion |
| - | Arg 476 | deletion |
| - | Glu 477 | deletion |
| - | Gly 478 | deletion |
| - | Arg 479 | deletion |
| - | Arg 480 | deletion |
| - | Arg 481 | deletion |
| - | Gly 482 | deletion |
| - | Pro 483 | deletion |
| - | Arg 484 | deletion |
| - | Arg 485 | deletion |
| - | Glu 486 | deletion |
| - | Ser 487 | deletion |
| - | Lys 488 | deletion |
| - | Pro 489 | deletion |
| - | Glu 490 | deletion |
| - | Glu 491 | deletion |
| - | Pro 492 | deletion |
| - | Pro 493 | deletion |
| - | Pro 494 | deletion |
| - | Pro 495 | deletion |
| - | Lys 496 | deletion |
| - | Lys 497 | deletion |
| - | Pro 498 | deletion |
| - | Ala 499 | deletion |
| - | Leu 500 | deletion |
| - | Asp 501 | deletion |
| - | Lys 502 | deletion |
| - | Gly 503 | deletion |
| - | Leu 504 | deletion |
| - | Gly 505 | deletion |
| - | Thr 506 | deletion |
| - | Gly 507 | deletion |
| - | Gln 508 | deletion |
| Thr 461 | Ala 510 | conflict |
| Ala 523 | Ser 512 | conflict |
| Thr 525 | Pro 514 | conflict |
| Ala 526 | Pro 515 | conflict |
| - | Lys 517 | deletion |
| - | Pro 518 | deletion |
| - | Pro 519 | deletion |
| - | Gly 520 | deletion |
| - | Thr 521 | deletion |
| - | Val 522 | deletion |
| - | Ala 523 | deletion |
| - | Gly 524 | deletion |
| - | Thr 525 | deletion |
| - | Ala 526 | deletion |
| - | Arg 527 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54833.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 695.8 | |
| All* | Total formula weight | 55529.1 |
