7O83
KRasG12C ligand complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b | polymer | 168 | 19094.5 | 2 | UniProt (A0A024RAV5) In PDB | Homo sapiens (Human) | |
| 2 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | A, B | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 4 | A, B | 1-[(7S)-11-chloro-12-(5-methyl-1H-indazol-4-yl)-9-oxa-2,5,15,17-tetrazatetracyclo[8.7.1.02,7.014,18]octadeca-1(17),10,12,14(18),15-pentaen-5-yl]prop-2-en-1-one | non-polymer | 462.9 | 2 | Chemie (V52) | |||
| 5 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 166 (UniProt: A0A024RAV5)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
| Ser 51 | Cys 51 | engineered mutation |
| Leu 80 | Cys 80 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
| Lys 167 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38189.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1901.0 | |
| All* | Total formula weight | 40089.9 |
