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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7O80

Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A2)		18S rRNApolymer1870603928.31GenBank (GBCT01000564.1)Oryctolagus cuniculus
2B
(AA)		40S ribosomal protein S27polymer849480.21UniProt (G1TZ76)
Pfam (PF01667)		Oryctolagus cuniculus (Rabbit)
3C
(AB)		Ribosomal protein S28polymer697855.11UniProt (G1TIB4)
Pfam (PF01200)		Oryctolagus cuniculus (Rabbit)
4D
(AC)		Ribosomal protein S27apolymer15618004.01UniProt (G1SK22)
Pfam (PF00240)
Pfam (PF01599)		Oryctolagus cuniculus (Rabbit)
5E
(AD)		40S ribosomal protein S30polymer13314498.91UniProt (G1T8A2)
Pfam (PF00240)
Pfam (PF04758)		Oryctolagus cuniculus (Rabbit)
6F
(AE)		Ribosomal protein eS26polymer11513047.51Oryctolagus cuniculus (Rabbit)
7G
(AF)		RACK1polymer31735115.71UniProt (G1SJB4)
Pfam (PF00400)		Oryctolagus cuniculus (Rabbit)
8H
(AG)		uS14polymer566690.81UniProt (G1U7M4)
Pfam (PF00253)		Oryctolagus cuniculus (Rabbit)
9I
(AH)		mRNA containing SARS-CoV-2 sequencepolymer21769683.01GenBank (NC_045512.2)Severe acute respiratory syndrome coronavirus 2
10J
(AI)		E-site tRNApolymer7615209.51Bos taurus
11K
(AT)		P-site Leu-tRNA(Leu)polymer8627761.51Bos taurus
12L
(AZ)		40S ribosomal protein SApolymer29532970.01UniProt (G1TLT8)
Pfam (PF00318)
Pfam (PF16122)		Oryctolagus cuniculus (Rabbit)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
13M
(Aa)		40S ribosomal protein S3apolymer26430002.11UniProt (G1SS70)
Pfam (PF01015)		Oryctolagus cuniculus (Rabbit)
14N
(Ab)		Ribosomal protein uS5polymer29331285.41Oryctolagus cuniculus (Rabbit)
15O
(Ac)		40S ribosomal protein S3polymer28131146.61UniProt (G1TNM3)
Pfam (PF07650)
Pfam (PF00189)		Oryctolagus cuniculus (Rabbit)uS3
16P
(Ad)		Ribosomal protein eS4polymer26329654.91Oryctolagus cuniculus (Rabbit)
17Q
(Ae)		Ribosomal protein S5polymer20422913.51UniProt (G1TFM5)
Pfam (PF00177)		Oryctolagus cuniculus (Rabbit)
18R
(Af)		40S ribosomal protein S6polymer24928751.91UniProt (G1TM55)
Pfam (PF01092)		Oryctolagus cuniculus (Rabbit)
19S
(Ag)		40S ribosomal protein S7polymer19422168.91UniProt (G1SVB0)
Pfam (PF01251)		Oryctolagus cuniculus (Rabbit)
20T
(Ah)		40S ribosomal protein S8polymer20824263.41UniProt (G1TJW1)
Pfam (PF01201)		Oryctolagus cuniculus (Rabbit)
21U
(Ai)		Ribosomal protein S9 (Predicted)polymer19422641.61UniProt (B7NZS8)
Pfam (PF00163)
Pfam (PF01479)		Oryctolagus cuniculus (Rabbit)
22V
(Aj)		Ribosomal protein eS10polymer16518933.81UniProt (G1TPV3)
Pfam (PF03501)
UniProt (by SIFTS) (G1T168)		Oryctolagus cuniculus (Rabbit)
23W
(Ak)		40S ribosomal protein S11polymer15818468.81UniProt (G1TRM4)
Pfam (PF16205)
Pfam (PF00366)		Oryctolagus cuniculus (Rabbit)
24X
(Al)		40S ribosomal protein S12polymer13214539.01UniProt (G1SFR8)
Pfam (PF01248)		Oryctolagus cuniculus (Rabbit)
25Y
(Am)		uS15polymer15117259.41UniProt (G1SP51)
Pfam (PF08069)
Pfam (PF00312)		Oryctolagus cuniculus (Rabbit)
26Z
(An)		40S ribosomal protein uS11polymer15116302.81UniProt (G1T1F0)
Pfam (PF00411)		Oryctolagus cuniculus (Rabbit)
27AA
(Ao)		40S ribosomal protein uS19polymer14517049.21UniProt (G1U0Q2)
Pfam (PF00203)		Oryctolagus cuniculus (Rabbit)
28BA
(Ap)		Ribosomal protein S16polymer14616477.41UniProt (G1SGX4)
Pfam (PF00380)		Oryctolagus cuniculus (Rabbit)
29CA
(Aq)		40S ribosomal protein eS17polymer13515552.11UniProt (G1TU13)
Pfam (PF00833)		Oryctolagus cuniculus (Rabbit)
30DA
(Ar)		40S ribosomal protein S18polymer15217801.81UniProt (G1TPG3)
Pfam (PF00416)		Oryctolagus cuniculus (Rabbit)
31EA
(As)		Ribosomal protein eS19polymer14516104.61Oryctolagus cuniculus (Rabbit)
32FA
(At)		40S ribosomal protein uS10polymer11913398.81UniProt (G1SIZ2)
Pfam (PF00338)		Oryctolagus cuniculus (Rabbit)
33GA
(Au)		Ribosomal protein eS21polymer839181.41Oryctolagus cuniculus (Rabbit)
34HA
(Av)		Ribosomal protein S15apolymer13014865.61UniProt (G1TG89)
Pfam (PF00410)		Oryctolagus cuniculus (Rabbit)
35IA
(Aw)		40S ribosomal protein S23polymer14315860.71UniProt (G1SZ47)
Pfam (PF00164)		Oryctolagus cuniculus (Rabbit)
36JA
(Ax)		40S ribosomal protein S24polymer13015107.91UniProt (G1T3D8)
Pfam (PF01282)
UniProt (by SIFTS) (A0A5F9D2E6)		Oryctolagus cuniculus (Rabbit)
37KA
(Ay)		40S ribosomal protein S25polymer12413645.01UniProt (G1TDB3)
Pfam (PF03297)		Oryctolagus cuniculus (Rabbit)
38LA
(Az)		60s ribosomal protein l41polymer253473.51UniProt (A0A087WNH4)
Pfam (PF05162)		Oryctolagus cuniculus (Rabbit)eL41
39MA
(B5)		28S rRNApolymer48081557519.51GenBank (GBCN01009604.1)Oryctolagus cuniculus
40NA
(B7)		5S rRNApolymer11938346.71GenBank (GBCM01014045.1)Oryctolagus cuniculus
41OA
(B8)		5.8S rRNApolymer15850809.01GenBank (GBCN01009604.1)Oryctolagus cuniculus
42PA
(BA)		Ribosomal protein uL2polymer25728103.91Oryctolagus cuniculus (Rabbit)
43QA
(BB)		Ribosomal protein L3polymer40346121.01UniProt (G1TL06)
Pfam (PF00297)		Oryctolagus cuniculus (Rabbit)
44RA
(BC)		60S ribosomal protein L4polymer41346430.91UniProt (G1SVW5)
Pfam (PF00573)
Pfam (PF14374)		Oryctolagus cuniculus (Rabbit)
45SA
(BD)		Ribosomal_L18_c domain-containing proteinpolymer29734523.91UniProt (G1SYJ6)
Pfam (PF17144)
Pfam (PF14204)
UniProt (by SIFTS) (P19949)		Oryctolagus cuniculus (Rabbit)
46TA
(BE)		60S ribosomal protein L6polymer29133028.31UniProt (G1SKF7)
Pfam (PF03868)
Pfam (PF01159)		Oryctolagus cuniculus (Rabbit)
47UA
(BF)		Ribosomal Protein uL30polymer24729201.81Oryctolagus cuniculus (Rabbit)
48VA
(BG)		Ribosomal protein eL8polymer26630061.81Oryctolagus cuniculus (Rabbit)
49WA
(BH)		60S ribosomal protein L9polymer19221871.41UniProt (G1SWI6)
Pfam (PF00347)		Oryctolagus cuniculus (Rabbit)
50XA
(BI)		60S ribosomal protein L10polymer21424643.11UniProt (B7NZQ2)
Pfam (PF00252)		Oryctolagus cuniculus (Rabbit)Ribosomal protein L10 (Predicted)
51YA
(BJ)		Ribosomal protein L11polymer17820288.51UniProt (G1TUB8)
Pfam (PF00281)
Pfam (PF00673)		Oryctolagus cuniculus (Rabbit)
52ZA
(BK)		Replicase polyprotein 1abpolymer1071121565.81UniProt (P0DTD1)
Pfam (PF09401)
Pfam (PF06478)
Pfam (PF00680)		Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)pp1ab,ORF1ab polyprotein
53AB
(BL)		Ribosomal protein eL13polymer21124331.71Oryctolagus cuniculus (Rabbit)
54BB
(BM)		Ribosomal protein L14polymer21823870.51UniProt (G1SZ12)
Pfam (PF01929)		Oryctolagus cuniculus (Rabbit)
55CB
(BN)		Ribosomal protein L15polymer20424207.31UniProt (G1T0C1)
Pfam (PF00827)		Oryctolagus cuniculus (Rabbit)
56DB
(BO)		Ribosomal protein L13apolymer20323533.31Oryctolagus cuniculus (Rabbit)
57EB
(BP)		uL22polymer18421444.21UniProt (G1TVT6)
Pfam (PF00237)
UniProt (by SIFTS) (G1SCJ6)		Oryctolagus cuniculus (Rabbit)
58FB
(BQ)		Ribosomal protein L18polymer18821699.71Oryctolagus cuniculus (Rabbit)
59GB
(BR)		60S ribosomal protein L19polymer19623535.31UniProt (Q3T0W9)
Pfam (PF01280)
Pfam (PF25476)		Oryctolagus cuniculus (Rabbit)
60HB
(BS)		Ribosomal protein L18apolymer17620749.41Oryctolagus cuniculus (Rabbit)
61IB
(BT)		eL21polymer16018610.01UniProt (G1SHQ2)
Pfam (PF01157)		Oryctolagus cuniculus (Rabbit)
62JB
(BU)		Ribosomal protein eL22polymer12814756.91Oryctolagus cuniculus (Rabbit)
63KB
(BV)		Ribosomal protein L23polymer14014892.51UniProt (G1T6D1)
Pfam (PF00238)		Oryctolagus cuniculus (Rabbit)
64LB
(BW)		eL24polymer15717825.11UniProt (G1SE28)
Pfam (PF01246)		Oryctolagus cuniculus (Rabbit)
65MB
(BX)		uL23polymer15617768.21UniProt (G1SE76)
Pfam (PF03939)
Pfam (PF00276)		Oryctolagus cuniculus (Rabbit)
66NB
(BY)		Ribosomal protein L26polymer14517303.41UniProt (G1SQH0)
Pfam (PF16906)
Pfam (PF00467)		Oryctolagus cuniculus (Rabbit)
67OB
(BZ)		60S ribosomal protein L27polymer13615835.81UniProt (G1TXF6)
Pfam (PF00467)
Pfam (PF01777)		Oryctolagus cuniculus (Rabbit)
68PB
(Ba)		60S ribosomal protein L27apolymer14816635.61UniProt (G1SNY0)
Pfam (PF00828)		Oryctolagus cuniculus (Rabbit)
69QB
(Bb)		60S ribosomal protein L29polymer24526721.71UniProt (G1SGR6)
Pfam (PF01779)		Oryctolagus cuniculus (Rabbit)
70RB
(Bc)		eL30polymer11512807.11UniProt (G1TDL2)
Pfam (PF01248)		Oryctolagus cuniculus (Rabbit)
71SB
(Bd)		eL31polymer12514494.91UniProt (G1SHG0)
Pfam (PF01198)		Oryctolagus cuniculus (Rabbit)
72TB
(Be)		eL32polymer13515898.91UniProt (G1U437)
Pfam (PF01655)
UniProt (by SIFTS) (G1TUN8)		Oryctolagus cuniculus (Rabbit)
73UB
(Bf)		eL33polymer11012580.81UniProt (G1SF08)
Pfam (PF01247)		Oryctolagus cuniculus (Rabbit)
74VB
(Bg)		60S ribosomal protein L34polymer11713326.11UniProt (G1TXG5)
Pfam (PF01199)		Oryctolagus cuniculus (Rabbit)
75WB
(Bh)		uL29polymer12314566.61UniProt (G1SIT5)
Pfam (PF00831)		Oryctolagus cuniculus (Rabbit)
76XB
(Bi)		60S ribosomal protein L36polymer10512263.81UniProt (G1TTQ5)
Pfam (PF01158)		Oryctolagus cuniculus (Rabbit)
77YB
(Bj)		Ribosomal protein L37polymer9711111.01UniProt (U3KPD5)
Pfam (PF01907)		Oryctolagus cuniculus (Rabbit)
78ZB
(Bk)		eL38polymer708238.91UniProt (G1U001)
Pfam (PF01781)		Oryctolagus cuniculus (Rabbit)
79AC
(Bl)		eL39polymer516455.81UniProt (G1TTN1)
Pfam (PF00832)
UniProt (by SIFTS) (G1SYU7)		Oryctolagus cuniculus (Rabbit)
80BC
(Bm)		60S ribosomal protein L40polymer12814800.51Oryctolagus cuniculus (Rabbit)
81CC
(Bo)		eL42polymer10612490.01UniProt (G1U344)
Pfam (PF00935)
UniProt (by SIFTS) (G1T040)		Oryctolagus cuniculus (Rabbit)
82DC
(Bp)		eL43polymer9210299.41UniProt (G1SY53)
Pfam (PF01780)		Oryctolagus cuniculus (Rabbit)
83EC
(Br)		Ribosomal protein eL28polymer13715844.71Oryctolagus cuniculus (Rabbit)
84FC
(Bs)		60S acidic ribosomal protein P0polymer31834380.51UniProt (G1SPK4)
Pfam (PF00466)
Pfam (PF17777)
Pfam (PF00428)		Oryctolagus cuniculus (Rabbit)
85GC
(Bt)		Ribosomal protein L12polymer16517847.61UniProt (G1SMR7)
Pfam (PF03946)
Pfam (PF00298)		Oryctolagus cuniculus (Rabbit)
86HC
(Bv)		Ribosomal proteinpolymer21724875.41UniProt (G1SKZ8)
Pfam (PF00687)		Oryctolagus cuniculus (Rabbit)
87IC
(By)		Eukaryotic peptide chain release factor subunit 1polymer43749120.81UniProt (P62497)
Pfam (PF03463)
Pfam (PF03464)
Pfam (PF03465)		Oryctolagus cuniculus (Rabbit)Eukaryotic release factor 1,eRF1
88JC
(Bz)		ATP binding cassette subfamily E member 1polymer59967405.21UniProt (G1SG72)
Pfam (PF04068)
Pfam (PF00037)
Pfam (PF00005)		Oryctolagus cuniculus (Rabbit)
89KC
(A2)		SPERMIDINEnon-polymer145.21Chemie (SPD)
PubChem (1102)
90AD, AE, AF, AG, AK...
(A2, B5, BP, B7, BR...)		MAGNESIUM IONnon-polymer24.3355Chemie (MG)
PubChem (888)
91AAA, ABA, ACA, ADA, AEA...
(B5, B8, BN, A2, BP...)		UNKNOWN ATOM OR IONnon-polymer374Chemie (UNX)
92HJ, IJ, JJ, OEA, QEA...
(AC, AE, AG, Bg, Bj...)		ZINC IONnon-polymer65.48Chemie (ZN)
93FCA
(B7)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
PubChem (177679032)
PubChem (135400627)
PubChem (135487750)
PubChem (136088935)
PubChem (136803486)
PubChem (135398633)
PubChem (135544356)
PubChem (135547949)
PubChem (135600366)
PubChem (135749822)
PubChem (136005188)
PubChem (136073923)
PubChem (136240914)
PubChem (136664747)
PubChem (136772743)
PubChem (136772744)
PubChem (136803487)
PubChem (137286749)
PubChem (164715984)
PubChem (171699466)
94VEA, WEA
(Bz)		IRON/SULFUR CLUSTERnon-polymer351.62Chemie (SF4)
95AFA, AGA, BFA, BGA, CFA...
(Aa, BV, Ab, BX, Ad...)		waterwater18.01737Chemie (HOH)
Sequence modifications
A2: 1 - 1870 (GenBank: GBCT01000564.1)
PDBExternal DatabaseDetails
B8n 1249C 3623conflict
4ac 1338C 3712conflict
4ac 1843C 4217conflict
AH: 3326 - 3542 (GenBank: NC_045512.2)
PDBExternal DatabaseDetails
U 3466A 13466conflict
A 3468C 13468conflict
Ah: 1 - 208 (UniProt: G1TJW1)
PDBExternal DatabaseDetails
Arg 47Gly 47conflict
B5: 1 - 4808 (GenBank: GBCN01009604.1)
PDBExternal DatabaseDetails
Uy1 3550U 5943conflict
BD: 1 - 297 (UniProt: G1SYJ6)
PDBExternal DatabaseDetails
Aac 2Gly 2conflict
Bk: 1 - 70 (UniProt: G1U001)
PDBExternal DatabaseDetails
Lys 24Asn 24conflict
By: 1 - 437 (UniProt: P62497)
PDBExternal DatabaseDetails
Ala 183Gly 183engineered mutation
Ala 184Gly 184engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains88
Total formula weight4146138.7
Non-Polymers*Number of molecules741
Total formula weight10523.3
All*Total formula weight4156661.9
*Water molecules are not included.

253389

PDB entries from 2026-05-13

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