7O80
Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A2) | 18S rRNA | polymer | 1870 | 603928.3 | 1 | GenBank (GBCT01000564.1) | Oryctolagus cuniculus | |
| 2 | B (AA) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (G1TZ76) Pfam (PF01667) | Oryctolagus cuniculus (Rabbit) | |
| 3 | C (AB) | Ribosomal protein S28 | polymer | 69 | 7855.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) | Oryctolagus cuniculus (Rabbit) | |
| 4 | D (AC) | Ribosomal protein S27a | polymer | 156 | 18004.0 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) | Oryctolagus cuniculus (Rabbit) | |
| 5 | E (AD) | 40S ribosomal protein S30 | polymer | 133 | 14498.9 | 1 | UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758) | Oryctolagus cuniculus (Rabbit) | |
| 6 | F (AE) | Ribosomal protein eS26 | polymer | 115 | 13047.5 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 7 | G (AF) | RACK1 | polymer | 317 | 35115.7 | 1 | UniProt (G1SJB4) Pfam (PF00400) | Oryctolagus cuniculus (Rabbit) | |
| 8 | H (AG) | uS14 | polymer | 56 | 6690.8 | 1 | UniProt (G1U7M4) Pfam (PF00253) | Oryctolagus cuniculus (Rabbit) | |
| 9 | I (AH) | mRNA containing SARS-CoV-2 sequence | polymer | 217 | 69683.0 | 1 | GenBank (NC_045512.2) | Severe acute respiratory syndrome coronavirus 2 | |
| 10 | J (AI) | E-site tRNA | polymer | 76 | 15209.5 | 1 | Bos taurus | ||
| 11 | K (AT) | P-site Leu-tRNA(Leu) | polymer | 86 | 27761.5 | 1 | Bos taurus | ||
| 12 | L (AZ) | 40S ribosomal protein SA | polymer | 295 | 32970.0 | 1 | UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122) | Oryctolagus cuniculus (Rabbit) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40 |
| 13 | M (Aa) | 40S ribosomal protein S3a | polymer | 264 | 30002.1 | 1 | UniProt (G1SS70) Pfam (PF01015) | Oryctolagus cuniculus (Rabbit) | |
| 14 | N (Ab) | Ribosomal protein uS5 | polymer | 293 | 31285.4 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 15 | O (Ac) | 40S ribosomal protein S3 | polymer | 281 | 31146.6 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) | Oryctolagus cuniculus (Rabbit) | uS3 |
| 16 | P (Ad) | Ribosomal protein eS4 | polymer | 263 | 29654.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 17 | Q (Ae) | Ribosomal protein S5 | polymer | 204 | 22913.5 | 1 | UniProt (G1TFM5) Pfam (PF00177) | Oryctolagus cuniculus (Rabbit) | |
| 18 | R (Af) | 40S ribosomal protein S6 | polymer | 249 | 28751.9 | 1 | UniProt (G1TM55) Pfam (PF01092) | Oryctolagus cuniculus (Rabbit) | |
| 19 | S (Ag) | 40S ribosomal protein S7 | polymer | 194 | 22168.9 | 1 | UniProt (G1SVB0) | Oryctolagus cuniculus (Rabbit) | |
| 20 | T (Ah) | 40S ribosomal protein S8 | polymer | 208 | 24263.4 | 1 | UniProt (G1TJW1) Pfam (PF01201) | Oryctolagus cuniculus (Rabbit) | |
| 21 | U (Ai) | Ribosomal protein S9 (Predicted) | polymer | 194 | 22641.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) | Oryctolagus cuniculus (Rabbit) | |
| 22 | V (Aj) | Ribosomal protein eS10 | polymer | 165 | 18933.8 | 1 | UniProt (G1TPV3) Pfam (PF03501) | Oryctolagus cuniculus (Rabbit) | |
| 23 | W (Ak) | 40S ribosomal protein S11 | polymer | 158 | 18468.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) | Oryctolagus cuniculus (Rabbit) | |
| 24 | X (Al) | 40S ribosomal protein S12 | polymer | 132 | 14539.0 | 1 | UniProt (G1SFR8) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 25 | Y (Am) | uS15 | polymer | 151 | 17259.4 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) | Oryctolagus cuniculus (Rabbit) | |
| 26 | Z (An) | 40S ribosomal protein uS11 | polymer | 151 | 16302.8 | 1 | UniProt (G1T1F0) Pfam (PF00411) | Oryctolagus cuniculus (Rabbit) | |
| 27 | AA (Ao) | 40S ribosomal protein uS19 | polymer | 145 | 17049.2 | 1 | UniProt (G1U0Q2) Pfam (PF00203) | Oryctolagus cuniculus (Rabbit) | |
| 28 | BA (Ap) | Ribosomal protein S16 | polymer | 146 | 16477.4 | 1 | UniProt (G1SGX4) Pfam (PF00380) | Oryctolagus cuniculus (Rabbit) | |
| 29 | CA (Aq) | 40S ribosomal protein eS17 | polymer | 135 | 15552.1 | 1 | UniProt (G1TU13) Pfam (PF00833) | Oryctolagus cuniculus (Rabbit) | |
| 30 | DA (Ar) | 40S ribosomal protein S18 | polymer | 152 | 17801.8 | 1 | UniProt (G1TPG3) Pfam (PF00416) | Oryctolagus cuniculus (Rabbit) | |
| 31 | EA (As) | Ribosomal protein eS19 | polymer | 145 | 16104.6 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 32 | FA (At) | 40S ribosomal protein uS10 | polymer | 119 | 13398.8 | 1 | UniProt (G1SIZ2) Pfam (PF00338) | Oryctolagus cuniculus (Rabbit) | |
| 33 | GA (Au) | Ribosomal protein eS21 | polymer | 83 | 9181.4 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 34 | HA (Av) | Ribosomal protein S15a | polymer | 130 | 14865.6 | 1 | UniProt (G1TG89) Pfam (PF00410) | Oryctolagus cuniculus (Rabbit) | |
| 35 | IA (Aw) | 40S ribosomal protein S23 | polymer | 143 | 15860.7 | 1 | UniProt (G1SZ47) Pfam (PF00164) | Oryctolagus cuniculus (Rabbit) | |
| 36 | JA (Ax) | 40S ribosomal protein S24 | polymer | 130 | 15107.9 | 1 | UniProt (G1T3D8) Pfam (PF01282) | Oryctolagus cuniculus (Rabbit) | |
| 37 | KA (Ay) | 40S ribosomal protein S25 | polymer | 124 | 13645.0 | 1 | UniProt (G1TDB3) Pfam (PF03297) | Oryctolagus cuniculus (Rabbit) | |
| 38 | LA (Az) | 60s ribosomal protein l41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (Rabbit) | eL41 |
| 39 | MA (B5) | 28S rRNA | polymer | 4808 | 1557519.5 | 1 | GenBank (GBCN01009604.1) | Oryctolagus cuniculus | |
| 40 | NA (B7) | 5S rRNA | polymer | 119 | 38346.7 | 1 | GenBank (GBCM01014045.1) | Oryctolagus cuniculus | |
| 41 | OA (B8) | 5.8S rRNA | polymer | 158 | 50809.0 | 1 | GenBank (GBCN01009604.1) | Oryctolagus cuniculus | |
| 42 | PA (BA) | Ribosomal protein uL2 | polymer | 257 | 28103.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 43 | QA (BB) | Ribosomal protein L3 | polymer | 403 | 46121.0 | 1 | UniProt (G1TL06) Pfam (PF00297) | Oryctolagus cuniculus (Rabbit) | |
| 44 | RA (BC) | 60S ribosomal protein L4 | polymer | 413 | 46430.9 | 1 | UniProt (G1SVW5) Pfam (PF00573) Pfam (PF14374) | Oryctolagus cuniculus (Rabbit) | |
| 45 | SA (BD) | Ribosomal_L18_c domain-containing protein | polymer | 297 | 34523.9 | 1 | UniProt (G1SYJ6) UniProt (by SIFTS) (P19949) | Oryctolagus cuniculus (Rabbit) | |
| 46 | TA (BE) | 60S ribosomal protein L6 | polymer | 291 | 33028.3 | 1 | UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159) | Oryctolagus cuniculus (Rabbit) | |
| 47 | UA (BF) | Ribosomal Protein uL30 | polymer | 247 | 29201.8 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 48 | VA (BG) | Ribosomal protein eL8 | polymer | 266 | 30061.8 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 49 | WA (BH) | 60S ribosomal protein L9 | polymer | 192 | 21871.4 | 1 | UniProt (G1SWI6) Pfam (PF00347) | Oryctolagus cuniculus (Rabbit) | |
| 50 | XA (BI) | 60S ribosomal protein L10 | polymer | 214 | 24643.1 | 1 | UniProt (B7NZQ2) Pfam (PF00252) | Oryctolagus cuniculus (Rabbit) | Ribosomal protein L10 (Predicted) |
| 51 | YA (BJ) | Ribosomal protein L11 | polymer | 178 | 20288.5 | 1 | UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673) | Oryctolagus cuniculus (Rabbit) | |
| 52 | ZA (BK) | Replicase polyprotein 1ab | polymer | 1071 | 121565.8 | 1 | UniProt (P0DTD1) Pfam (PF09401) Pfam (PF06478) Pfam (PF00680) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | pp1ab,ORF1ab polyprotein |
| 53 | AB (BL) | Ribosomal protein eL13 | polymer | 211 | 24331.7 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 54 | BB (BM) | Ribosomal protein L14 | polymer | 218 | 23870.5 | 1 | UniProt (G1SZ12) Pfam (PF01929) | Oryctolagus cuniculus (Rabbit) | |
| 55 | CB (BN) | Ribosomal protein L15 | polymer | 204 | 24207.3 | 1 | UniProt (G1T0C1) Pfam (PF00827) | Oryctolagus cuniculus (Rabbit) | |
| 56 | DB (BO) | Ribosomal protein L13a | polymer | 203 | 23533.3 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 57 | EB (BP) | uL22 | polymer | 184 | 21444.2 | 1 | UniProt (G1TVT6) Pfam (PF00237) UniProt (by SIFTS) (G1SCJ6) | Oryctolagus cuniculus (Rabbit) | |
| 58 | FB (BQ) | Ribosomal protein L18 | polymer | 188 | 21699.7 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 59 | GB (BR) | 60S ribosomal protein L19 | polymer | 196 | 23535.3 | 1 | UniProt (Q3T0W9) Pfam (PF01280) | Oryctolagus cuniculus (Rabbit) | |
| 60 | HB (BS) | Ribosomal protein L18a | polymer | 176 | 20749.4 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 61 | IB (BT) | eL21 | polymer | 160 | 18610.0 | 1 | UniProt (G1SHQ2) Pfam (PF01157) | Oryctolagus cuniculus (Rabbit) | |
| 62 | JB (BU) | Ribosomal protein eL22 | polymer | 128 | 14756.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 63 | KB (BV) | Ribosomal protein L23 | polymer | 140 | 14892.5 | 1 | UniProt (G1T6D1) Pfam (PF00238) | Oryctolagus cuniculus (Rabbit) | |
| 64 | LB (BW) | eL24 | polymer | 157 | 17825.1 | 1 | UniProt (G1SE28) Pfam (PF01246) | Oryctolagus cuniculus (Rabbit) | |
| 65 | MB (BX) | uL23 | polymer | 156 | 17768.2 | 1 | UniProt (G1SE76) Pfam (PF03939) Pfam (PF00276) | Oryctolagus cuniculus (Rabbit) | |
| 66 | NB (BY) | Ribosomal protein L26 | polymer | 145 | 17303.4 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) | Oryctolagus cuniculus (Rabbit) | |
| 67 | OB (BZ) | 60S ribosomal protein L27 | polymer | 136 | 15835.8 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) | Oryctolagus cuniculus (Rabbit) | |
| 68 | PB (Ba) | 60S ribosomal protein L27a | polymer | 148 | 16635.6 | 1 | UniProt (G1SNY0) Pfam (PF00828) | Oryctolagus cuniculus (Rabbit) | |
| 69 | QB (Bb) | 60S ribosomal protein L29 | polymer | 245 | 26721.7 | 1 | UniProt (G1SGR6) Pfam (PF01779) | Oryctolagus cuniculus (Rabbit) | |
| 70 | RB (Bc) | eL30 | polymer | 115 | 12807.1 | 1 | UniProt (G1TDL2) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 71 | SB (Bd) | eL31 | polymer | 125 | 14494.9 | 1 | UniProt (G1SHG0) Pfam (PF01198) | Oryctolagus cuniculus (Rabbit) | |
| 72 | TB (Be) | eL32 | polymer | 135 | 15898.9 | 1 | UniProt (G1U437) Pfam (PF01655) UniProt (by SIFTS) (G1TUN8) | Oryctolagus cuniculus (Rabbit) | |
| 73 | UB (Bf) | eL33 | polymer | 110 | 12580.8 | 1 | UniProt (G1SF08) Pfam (PF01247) | Oryctolagus cuniculus (Rabbit) | |
| 74 | VB (Bg) | 60S ribosomal protein L34 | polymer | 117 | 13326.1 | 1 | UniProt (G1TXG5) Pfam (PF01199) | Oryctolagus cuniculus (Rabbit) | |
| 75 | WB (Bh) | uL29 | polymer | 123 | 14566.6 | 1 | UniProt (G1SIT5) Pfam (PF00831) | Oryctolagus cuniculus (Rabbit) | |
| 76 | XB (Bi) | 60S ribosomal protein L36 | polymer | 105 | 12263.8 | 1 | UniProt (G1TTQ5) Pfam (PF01158) | Oryctolagus cuniculus (Rabbit) | |
| 77 | YB (Bj) | Ribosomal protein L37 | polymer | 97 | 11111.0 | 1 | UniProt (U3KPD5) Pfam (PF01907) | Oryctolagus cuniculus (Rabbit) | |
| 78 | ZB (Bk) | eL38 | polymer | 70 | 8238.9 | 1 | UniProt (G1U001) Pfam (PF01781) | Oryctolagus cuniculus (Rabbit) | |
| 79 | AC (Bl) | eL39 | polymer | 51 | 6455.8 | 1 | UniProt (G1TTN1) Pfam (PF00832) | Oryctolagus cuniculus (Rabbit) | |
| 80 | BC (Bm) | 60S ribosomal protein L40 | polymer | 128 | 14800.5 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 81 | CC (Bo) | eL42 | polymer | 106 | 12490.0 | 1 | UniProt (G1U344) Pfam (PF00935) UniProt (by SIFTS) (G1T040) | Oryctolagus cuniculus (Rabbit) | |
| 82 | DC (Bp) | eL43 | polymer | 92 | 10299.4 | 1 | UniProt (G1SY53) Pfam (PF01780) | Oryctolagus cuniculus (Rabbit) | |
| 83 | EC (Br) | Ribosomal protein eL28 | polymer | 137 | 15844.7 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 84 | FC (Bs) | 60S acidic ribosomal protein P0 | polymer | 318 | 34380.5 | 1 | UniProt (G1SPK4) Pfam (PF00466) Pfam (PF17777) Pfam (PF00428) | Oryctolagus cuniculus (Rabbit) | |
| 85 | GC (Bt) | Ribosomal protein L12 | polymer | 165 | 17847.6 | 1 | UniProt (G1SMR7) Pfam (PF03946) Pfam (PF00298) | Oryctolagus cuniculus (Rabbit) | |
| 86 | HC (Bv) | Ribosomal protein | polymer | 217 | 24875.4 | 1 | UniProt (G1SKZ8) Pfam (PF00687) | Oryctolagus cuniculus (Rabbit) | |
| 87 | IC (By) | Eukaryotic peptide chain release factor subunit 1 | polymer | 437 | 49120.8 | 1 | UniProt (P62497) Pfam (PF03463) Pfam (PF03464) Pfam (PF03465) | Oryctolagus cuniculus (Rabbit) | Eukaryotic release factor 1,eRF1 |
| 88 | JC (Bz) | ATP binding cassette subfamily E member 1 | polymer | 599 | 67405.2 | 1 | UniProt (G1SG72) Pfam (PF04068) Pfam (PF00037) Pfam (PF00005) | Oryctolagus cuniculus (Rabbit) | |
| 89 | KC (A2) | SPERMIDINE | non-polymer | 145.2 | 1 | Chemie (SPD) | |||
| 90 | AD, AE, AF, AG, AK... (A2, B5, BP, B7, BR...) | MAGNESIUM ION | non-polymer | 24.3 | 355 | Chemie (MG) | |||
| 91 | AAA, ABA, ACA, ADA, AEA... (B5, B8, BN, A2, BP...) | UNKNOWN ATOM OR ION | non-polymer | 374 | Chemie (UNX) | ||||
| 92 | HJ, IJ, JJ, OEA, QEA... (AC, AE, AG, Bg, Bj...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 93 | FCA (B7) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 94 | VEA, WEA (Bz) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 2 | Chemie (SF4) | |||
| 95 | AFA, AGA, BFA, BGA, CFA... (Aa, BV, Ab, BX, Ad...) | water | water | 18.0 | 1737 | Chemie (HOH) |
Sequence modifications
A2: 1 - 1870 (GenBank: GBCT01000564.1)
AH: 3326 - 3542 (GenBank: NC_045512.2)
Ah: 1 - 208 (UniProt: G1TJW1)
B5: 1 - 4808 (GenBank: GBCN01009604.1)
BD: 1 - 297 (UniProt: G1SYJ6)
Bk: 1 - 70 (UniProt: G1U001)
By: 1 - 437 (UniProt: P62497)
| PDB | External Database | Details |
|---|---|---|
| B8n 1249 | C 3623 | conflict |
| 4ac 1338 | C 3712 | conflict |
| 4ac 1843 | C 4217 | conflict |
| PDB | External Database | Details |
|---|---|---|
| U 3466 | A 13466 | conflict |
| A 3468 | C 13468 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Uy1 3550 | U 5943 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Aac 2 | Gly 2 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Lys 24 | Asn 24 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 183 | Gly 183 | engineered mutation |
| Ala 184 | Gly 184 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 88 |
| Total formula weight | 4146138.7 | |
| Non-Polymers* | Number of molecules | 741 |
| Total formula weight | 10523.3 | |
| All* | Total formula weight | 4156661.9 |
