7O70

KRasG12C ligand complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	GTPase KRas	polymer	170	19352.8	2	UniProt (P01116) Pfam (PF00071) In PDB	Homo sapiens (Human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	A, D	1-[(4R,7S)-12-chloro-14-fluoro-13-(2-fluoro-6-hydroxyphenyl)-4-methyl-10-oxa-2,5,16,18-tetrazatetracyclo[9.7.1.0^(2,7).0^(15,19)]nonadeca-1(18),11,13,15(19),16-pentaen-5-en-1-one-yl]prop-2	non-polymer		486.9	2	Chemie (V4T)
3	A, D	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A, D	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
5	A, D	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
6		water	water		18.0	374	Chemie (HOH)

Sequence modifications

A, D: 1 - 169 (UniProt: P01116)

PDB	External Database	Details
Gly 0	-	expression tag
Cys 12	Gly 12	engineered mutation
Ser 51	Cys 51	engineered mutation
Leu 80	Cys 80	engineered mutation
Ser 118	Cys 118	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38705.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1989.0
All*	Total formula weight	40694.5

*Water molecules are not included.