7O6R
Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with 1H-Indazole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heat shock cognate 71 kDa protein | polymer | 554 | 60978.9 | 1 | UniProt (P19120) Pfam (PF00012) | Bos taurus (Bovine) | Heat shock 70 kDa protein 8 |
| 2 | B (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 3 | C (A) | 1H-indazole | non-polymer | 118.1 | 1 | Chemie (LZ1) | |||
| 4 | D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F, G (A) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 7 | H (A) | trimethylamine oxide | non-polymer | 75.1 | 1 | Chemie (TMO) | |||
| 8 | I (A) | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
A: 1 - 554 (UniProt: P19120)
| PDB | External Database | Details |
|---|---|---|
| Ala 213 | Glu 213 | engineered mutation |
| Ala 214 | Asp 214 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 60978.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 680.0 | |
| All* | Total formula weight | 61658.8 |
