7O2V

AURORA KINASE A IN COMPLEX WITH THE AUR-A/PDK1 INHIBITOR VI8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Aurora kinase A	polymer	299	34874.8	1	UniProt (O14965) Pfam (PF00069) In PDB	Homo sapiens (Human)	Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
2	A	1-[[3,4-bis(fluoranyl)phenyl]methyl]-~{N}-[(1~{R})-2-[[(3~{E})-3-(1~{H}-imidazol-5-ylmethylidene)-2-oxidanylidene-1~{H}-indol-5-yl]amino]-2-oxidanylidene-1-phenyl-ethyl]-6-methyl-2-oxidanylidene-pyridine-3-carboxamide	non-polymer		620.6	1	Chemie (V0K)
3		water	water		18.0	19	Chemie (HOH)

Sequence modifications

A: 116 - 403 (UniProt: O14965)

PDB	External Database	Details
Ser 105	-	expression tag
His 106	-	expression tag
His 107	-	expression tag
His 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
His 114	-	expression tag
His 115	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34874.8
Non-Polymers*	Number of molecules	1
	Total formula weight	620.6
All*	Total formula weight	35495.4

*Water molecules are not included.