7O2M
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2289
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Genome polyprotein | polymer | 53 | 5865.4 | 1 | UniProt (H8XX12) Pfam (PF01002) UniProt (by SIFTS) (Q32ZE1) | Zika virus (ZIKV) | |
| 2 | B (B) | Genome polyprotein | polymer | 178 | 19037.6 | 1 | UniProt (H8XX12) Pfam (PF00949) UniProt (by SIFTS) (Q32ZE1) | Zika virus (ZIKV) | |
| 3 | C (B) | 1-[(3~{S},6~{S},9~{S},19~{R})-3,6-bis(4-azanylbutyl)-2,5,8,12,15,18-hexakis(oxidanylidene)-9-(phenylmethyl)-1,4,7,11,14,17-hexazacyclotricos-19-yl]guanidine | non-polymer | 701.9 | 1 | Chemie (UZZ) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 109 | Chemie (HOH) |
Sequence modifications
A: 45 - 96 (UniProt: H8XX12)
B: 1 - 177 (UniProt: H8XX12)
| PDB | External Database | Details |
|---|---|---|
| Met 44 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24903.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 701.9 | |
| All* | Total formula weight | 25604.8 |
