7O1Y

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 0.25 M NaCl

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Furin	polymer	480	52112.3	1	UniProt (P09958) Pfam (PF00082) Pfam (PF01483)	Homo sapiens (Human)	Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE
2	B, C, D (A)	[[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]hydrazinylidene]methyl]phenyl]methylidene]hydrazinyl]-azanyl-methylidene]azanium	non-polymer		248.3	3	Chemie (UYQ)
3	E, F, G (A)	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
4	H, I (A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5	J (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	K, L, M, N, O... (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	8	Chemie (DMS)
7	S (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
8	T (A)	water	water		18.0	466	Chemie (HOH)

Sequence modifications

A: 108 - 574 (UniProt: P09958)

PDB	External Database	Details
Ser 575	-	expression tag
Gly 576	-	expression tag
Ser 577	-	expression tag
Leu 578	-	expression tag
Val 579	-	expression tag
Pro 580	-	expression tag
Arg 581	-	expression tag
Gly 582	-	expression tag
Ser 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag
His 586	-	expression tag
His 587	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52112.3
Non-Polymers*	Number of molecules	18
	Total formula weight	1792.8
All*	Total formula weight	53905.1

*Water molecules are not included.