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7NYG

14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-127

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
14-3-3 protein sigmapolymer23626558.91UniProt (P31947)
Pfam (PF00244)
Homo sapiens (Human)Epithelial cell marker protein 1,Stratifin
2B
(P)
Transcription factor p65polymer131412.41UniProt (Q04206)Homo sapiensNuclear factor NF-kappa-B p65 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
3C
(A)
4-[(2~{S})-2-methylpyrrolidin-1-yl]sulfonylbenzaldehydenon-polymer253.31Chemie (UVT)
4D
(A)
CHLORIDE IONnon-polymer35.51Chemie (CL)
5E
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
6F
(P)
GLYCEROLnon-polymer92.11Chemie (GOL)
7G, H
(A, P)
waterwater18.0304Chemie (HOH)
Sequence modifications
A: 1 - 231 (UniProt: P31947)
PDBExternal DatabaseDetails
Gly -4-expression tag
Ala -3-expression tag
Met -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
P: 39 - 51 (UniProt: Q04206)
PDBExternal DatabaseDetails
Arg 49Glu 49variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight27971.3
Non-Polymers*Number of molecules4
Total formula weight405.2
All*Total formula weight28376.5
*Water molecules are not included.

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PDB entries from 2024-11-13

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