7NYE
14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-134
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 236 | 26558.9 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (Human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (P) | Transcription factor p65 | polymer | 13 | 1412.4 | 1 | UniProt (Q04206) | Homo sapiens | Nuclear factor NF-kappa-B p65 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 |
| 3 | C (A) | 4-(4-propan-2-ylpiperazin-1-yl)sulfonylbenzaldehyde | non-polymer | 296.4 | 1 | Chemie (UVH) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E, F (A, P) | water | water | 18.0 | 297 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
P: 39 - 51 (UniProt: Q04206)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Arg 49 | Glu 49 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27971.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 388.5 | |
| All* | Total formula weight | 28359.8 |
