7NXY
14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-181
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 236 | 26558.9 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (Human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (P) | Transcription factor p65 | polymer | 13 | 1412.4 | 1 | UniProt (Q04206) | Homo sapiens | Nuclear factor NF-kappa-B p65 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 |
| 3 | C (A) | 4-[(6-fluoranyl-3,4-dihydro-2~{H}-quinolin-1-yl)sulfonyl]benzaldehyde | non-polymer | 319.4 | 1 | Chemie (UVQ) | |||
| 4 | D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | G (P) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | H, I (A, P) | water | water | 18.0 | 258 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
P: 39 - 51 (UniProt: Q04206)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Arg 49 | Glu 49 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27971.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 520.7 | |
| All* | Total formula weight | 28492.0 |
