7NXK
Crystal structure of human Cdk12/Cyclin K in complex with the inhibitor BSJ-01-175
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Cyclin-dependent kinase 12 | polymer | 351 | 40765.0 | 2 | UniProt (Q9NYV4) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cdc2-related kinase,arginine/serine-rich,CrkRS,Cell division cycle 2-related protein kinase 7,CDC2-related protein kinase 7,Cell division protein kinase 12,hCDK12 |
| 2 | B, D | Cyclin-K | polymer | 268 | 31429.2 | 2 | UniProt (O75909) Pfam (PF00134) Pfam (PF21797) In PDB | Homo sapiens (Human) | |
| 3 | A, C | (E)-N-[4-[(1R,3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide | non-polymer | 545.1 | 2 | Chemie (UUB) | |||
| 4 | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A, C: 714 - 1063 (UniProt: Q9NYV4)
B, D: 1 - 267 (UniProt: O75909)
| PDB | External Database | Details |
|---|---|---|
| Gly 713 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 144388.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1090.2 | |
| All* | Total formula weight | 145478.5 |
