7NXJ
Crystal structure of human Cdk13/Cyclin K in complex with the inhibitor THZ531
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Cyclin-dependent kinase 13 | polymer | 347 | 40521.9 | 2 | UniProt (Q14004) Pfam (PF00069) In PDB | Homo sapiens (Human) | CDC2-related protein kinase 5,Cell division cycle 2-like protein kinase 5,Cell division protein kinase 13,hCDK13,Cholinesterase-related cell division controller |
2 | B, D | Cyclin-K | polymer | 268 | 31429.2 | 2 | UniProt (O75909) Pfam (PF00134) Pfam (PF21797) In PDB | Homo sapiens (Human) | |
3 | A, C | N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide | non-polymer | 560.1 | 2 | Chemie (5I1) | |||
4 | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A, C: 694 - 1039 (UniProt: Q14004)
B, D: 1 - 267 (UniProt: O75909)
PDB | External Database | Details |
---|---|---|
Gly 693 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 143902.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1120.2 | |
All* | Total formula weight | 145022.3 |