7NX9
Crystal structure of the N501Y mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | H | EY6A Fab heavy chain | polymer | 226 | 24346.3 | 1 | Homo sapiens | ||
| 2 | L | EY6A Fab light chain | polymer | 215 | 23315.9 | 1 | Homo sapiens | ||
| 3 | E | Spike protein S1 | polymer | 205 | 23200.0 | 1 | UniProt (P0DTC2) Pfam (PF09408) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | |
| 4 | A | COVOX-222 Fab heavy chain | polymer | 224 | 23461.2 | 1 | Homo sapiens | ||
| 5 | B | COVOX-222 Fab light chain | polymer | 214 | 23327.9 | 1 | Homo sapiens | ||
| 6 | H, E, A, B | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 7 | E | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 8 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 9 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 10 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 11 | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
E: 333 - 528 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Glu 324 | - | expression tag |
| Thr 325 | - | expression tag |
| Gly 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| Tyr 501 | Asn 501 | engineered mutation |
| Lys 527 | Pro 527 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 117651.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1599.7 | |
| All* | Total formula weight | 119250.8 |
