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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7NWG

Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(51)		28S Ribosomal RNApolymer37881226619.41Oryctolagus cuniculus
2B
(71)		5S Ribosomal RNApolymer12038691.91GenBank (4CXE_4)Oryctolagus cuniculus
3C
(81)		5.8S Ribosomal RNApolymer15148545.71Oryctolagus cuniculus
4D
(A2)		18S Ribosomal RNApolymer1818586374.91Oryctolagus cuniculus
5E
(B2)		40S ribosomal protein SApolymer29532958.01UniProt (G1TLT8)
Pfam (PF00318)
Pfam (PF16122)		Oryctolagus cuniculus (Rabbit)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
6F
(C2)		40S ribosomal protein S3apolymer26429942.01UniProt (G1SS70)
Pfam (PF01015)		Oryctolagus cuniculus (Rabbit)
7G
(D2)		40S ribosomal protein S2polymer25927995.71Oryctolagus cuniculus (Bovine)
8H
(E2)		40S ribosomal protein S3polymer28131146.61UniProt (G1TNM3)
Pfam (PF07650)
Pfam (PF00189)		Oryctolagus cuniculus (Rabbit)
9I
(F2)		S4polymer26229523.71Oryctolagus cuniculus
10J
(G2)		Ribosomal protein S5polymer20523044.71UniProt (G1TFM5)
Pfam (PF00177)		Oryctolagus cuniculus (Rabbit)
11K
(H2)		40S ribosomal protein S6polymer26230070.41UniProt (A0A5K1UJS7)
Pfam (PF01092)		Oryctolagus cuniculus (Rabbit)
12L
(I2)		ribosomal protein eS7polymer19021716.41UniProt (G1SVB0)Oryctolagus cuniculus (Rabbit)
13M
(J2)		40S ribosomal protein S8polymer20624003.01UniProt (G1TJW1)
Pfam (PF01201)		Oryctolagus cuniculus (Rabbit)
14N
(K2)		40S ribosomal protein S9polymer19422655.61UniProt (A0A1S3APZ1)
Pfam (PF00163)
Pfam (PF01479)		Oryctolagus cuniculus (Rabbit)
15O
(L2)		40S ribosomal protein S10polymer15117422.11UniProt (A0A2F0BDG8)Oryctolagus cuniculus (Rabbit)
16P
(M2)		40S ribosomal protein S11polymer15818513.81UniProt (G1TRM4)
Pfam (PF16205)
Pfam (PF00366)		Oryctolagus cuniculus (Rabbit)
17Q
(N2)		40S ribosomal protein S12polymer12313709.11UniProt (G1SFR8)
Pfam (PF01248)		Oryctolagus cuniculus (Rabbit)
18R
(O2)		ribosomal protein uS15polymer14917057.11UniProt (G1SP51)
Pfam (PF08069)
Pfam (PF00312)		Oryctolagus cuniculus (Rabbit)
19S
(P2)		uS11polymer16818134.01UniProt (G1T1F0)
Pfam (PF00411)		Oryctolagus cuniculus (Rabbit)
20T
(Q2)		40S ribosomal protein uS19polymer14517049.21UniProt (G1U0Q2)
Pfam (PF00203)		Oryctolagus cuniculus (Rabbit)
21U
(R2)		Ribosomal protein S16polymer15717585.71UniProt (G1SGX4)
Pfam (PF00380)		Oryctolagus cuniculus (Rabbit)
22V
(S2)		40S ribosomal protein S17polymer14516782.61UniProt (S7Q348)
Pfam (PF00833)		Oryctolagus cuniculus (Rabbit)
23W
(T2)		40S ribosomal protein uS13polymer15217759.81UniProt (G1TPG3)
Pfam (PF00416)		Oryctolagus cuniculus (Rabbit)
24X
(U2)		S19polymer14516106.61UniProt (G1TN62)
Pfam (PF01090)		Oryctolagus cuniculus (Rabbit)
25Y
(V2)		40S ribosomal protein S20polymer13014603.11Oryctolagus cuniculus
26Z
(W2)		40S ribosomal protein S21polymer839124.41UniProt (Q32PB8)
Pfam (PF01249)		Oryctolagus cuniculus
27AA
(X2)		Ribosomal protein S15apolymer13915778.61Oryctolagus cuniculus (Rabbit)
28BA
(Y2)		Ribosomal protein S23polymer14115626.41UniProt (G1SZ47)
Pfam (PF00164)		Oryctolagus cuniculus (Rabbit)
29CA
(Z2)		40S ribosomal protein S24polymer14617007.11Oryctolagus cuniculus (Rabbit)
30DA
(a2)		ribosomal protein eS25polymer19822090.11Oryctolagus cuniculus (Rabbit)
31EA
(b2)		40S ribosomal protein S26polymer11713147.61UniProt (T0M5X4)Oryctolagus cuniculus (Rabbit)
32FA
(c2)		40S ribosomal protein S27polymer849480.21UniProt (G1TZ76)
Pfam (PF01667)		Oryctolagus cuniculus (Rabbit)
33GA
(d2)		40S ribosomal protein S28polymer697836.01UniProt (G1TIB4)
Pfam (PF01200)		Oryctolagus cuniculus (Rabbit)
34HA
(e2)		uS14polymer556559.61UniProt (G1U7M4)
Pfam (PF00253)		Oryctolagus cuniculus (Rabbit)
35IA
(f2)		40S ribosomal protein S30polymer13314498.91UniProt (G1T8A2)
Pfam (PF00240)
Pfam (PF04758)		Oryctolagus cuniculus (Rabbit)
36JA
(g2)		eS31polymer687986.41UniProt (G1SK22)
Pfam (PF00240)
Pfam (PF01599)		Oryctolagus cuniculus (Rabbit)
37KA
(h2)		ribosomal protein RACK1polymer31334669.11UniProt (G1SJB4)
Pfam (PF00400)		Oryctolagus cuniculus (Rabbit)
38LA
(A3)		L8polymer24626840.51Oryctolagus cuniculus
39MA
(B3)		uL3polymer40346108.01UniProt (G1TL06)
Pfam (PF00297)		Oryctolagus cuniculus (Rabbit)
40NA
(C3)		uL4polymer42547727.61UniProt (G1SVW5)
Pfam (PF00573)
Pfam (PF14374)		Oryctolagus cuniculus (Rabbit)
41OA
(D3)		60S ribosomal protein L5polymer29734481.81UniProt (G1SYJ6)
UniProt (by SIFTS) (P19949)		Oryctolagus cuniculus (Rabbit)
42PA
(E3)		60S ribosomal protein L6polymer29133028.31UniProt (G1SKF7)
Pfam (PF03868)
Pfam (PF01159)		Oryctolagus cuniculus (Rabbit)
43QA
(F3)		uL30polymer24929514.31UniProt (G1SV32)
Pfam (PF08079)
Pfam (PF00327)		Oryctolagus cuniculus (Rabbit)
44RA
(G3)		L7apolymer24127480.61UniProt (G1STW0)
Pfam (PF01248)		Oryctolagus cuniculus (Rabbit)
45SA
(H3)		L9polymer19021627.21UniProt (G1SWI6)
Pfam (PF00347)		Oryctolagus cuniculus (Rabbit)
46TA
(I3)		60S ribosomal protein L10polymer21424643.11UniProt (B7NZQ2)
Pfam (PF00252)		Oryctolagus cuniculus (Rabbit)Ribosomal protein L10 (Predicted)
47UA
(J3)		60S ribosomal protein L11polymer18120670.91UniProt (G1TUB8)
Pfam (PF00281)
Pfam (PF00673)		Oryctolagus cuniculus (Rabbit)
48VA
(L3)		L13polymer21124331.71UniProt (G1TKB3)
Pfam (PF01294)		Oryctolagus cuniculus (Rabbit)
49WA
(M3)		Ribosomal protein L14polymer21823870.51UniProt (G1SZ12)
Pfam (PF01929)		Oryctolagus cuniculus (Rabbit)
50XA
(N3)		Ribosomal protein L15polymer20324076.11UniProt (G1T0C1)
Pfam (PF00827)		Oryctolagus cuniculus (Rabbit)
51YA
(O3)		60S RIBOSOMAL PROTEIN UL13polymer20323533.31Oryctolagus cuniculus
52ZA
(P3)		uL22polymer19923056.21Oryctolagus cuniculus (Rabbit)
53AB
(Q3)		L18polymer18821699.71Oryctolagus cuniculus
54BB
(R3)		60S ribosomal protein L19polymer19623535.31UniProt (Q3T0W9)
Pfam (PF01280)		Oryctolagus cuniculus (Rabbit)
55CB
(S3)		60S ribosomal protein L18apolymer17620827.61UniProt (A0A287APR1)
Pfam (PF01775)		Oryctolagus cuniculus
56DB
(T3)		eL21polymer15918478.81UniProt (G1SHQ2)
Pfam (PF01157)		Oryctolagus cuniculus (Rabbit)
57EB
(U3)		L22polymer12814799.01Oryctolagus cuniculus
58FB
(V3)		eL14polymer13113972.41UniProt (G1T6D1)
Pfam (PF00238)		Oryctolagus cuniculus (Rabbit)
59GB
(X3)		uL23polymer15617768.21UniProt (G1SE76)
Pfam (PF03939)
Pfam (PF00276)		Oryctolagus cuniculus (Rabbit)
60HB
(Y3)		Ribosomal protein L26polymer13215705.61UniProt (G1SQH0)
Pfam (PF16906)
Pfam (PF00467)		Oryctolagus cuniculus (Rabbit)
61IB
(Z3)		60S ribosomal protein L27polymer13515704.61UniProt (G1TXF6)
Pfam (PF00467)
Pfam (PF01777)		Oryctolagus cuniculus (Rabbit)
62JB
(a3)		uL15polymer16017831.91Oryctolagus cuniculus (Rabbit)
63KB
(b3)		eL29polymer24526708.71UniProt (G1SGR6)
Pfam (PF01779)		Oryctolagus cuniculus (Rabbit)
64LB
(c3)		eL30polymer11512807.11UniProt (G1TDL2)
Pfam (PF01248)		Oryctolagus cuniculus (Rabbit)
65MB
(d3)		eL31polymer10712635.71UniProt (G1SHG0)
Pfam (PF01198)		Oryctolagus cuniculus (Rabbit)
66NB
(e3)		eL32polymer12815022.01UniProt (G1TUN8)
Pfam (PF01655)		Oryctolagus cuniculus (Rabbit)
67OB
(f3)		eL33polymer10912449.61UniProt (G1SF08)
Pfam (PF01247)		Oryctolagus cuniculus (Rabbit)
68PB
(g3)		60S ribosomal protein L34polymer12614210.11UniProt (G1U945)
Pfam (PF01199)
UniProt (by SIFTS) (G1TXG5)		Oryctolagus cuniculus (Rabbit)
69QB
(h3)		uL29polymer12214435.41UniProt (G1SIT5)
Pfam (PF00831)		Oryctolagus cuniculus (Rabbit)
70RB
(i3)		60S ribosomal protein L36polymer11713546.31Oryctolagus cuniculus (Rabbit)
71SB
(j3)		Ribosomal protein L37polymer9711111.01UniProt (U3KPD5)
Pfam (PF01907)		Oryctolagus cuniculus (Rabbit)
72TB
(k3)		L38polymer698107.81Oryctolagus cuniculus
73UB
(l3)		eL39polymer506324.61UniProt (G1TTN1)
Pfam (PF00832)
UniProt (by SIFTS) (G1SYU7)		Oryctolagus cuniculus (Rabbit)
74VB
(m3)		60S RIBOSOMAL PROTEIN EL40polymer12814695.31Oryctolagus cuniculus
75WB
(n3)		60s ribosomal protein l41polymer253473.51UniProt (A0A087WNH4)
Pfam (PF05162)		Oryctolagus cuniculus (Rabbit)eL41
76XB
(o3)		eL42polymer14216170.21Oryctolagus cuniculus (Rabbit)
77YB
(p3)		ribosomal protein eL43polymer10912010.41Oryctolagus cuniculus (Rabbit)
78ZB
(r3)		eL28polymer13715783.61UniProt (G1U7L1)
Pfam (PF01778)		Oryctolagus cuniculus (Rabbit)
79AC
(q3)		A/P-Site tRNApolymer7423825.21Oryctolagus cuniculus
80BC
(t3)		60S acidic ribosomal protein P0polymer31834380.51UniProt (G1SPK4)
Pfam (PF00466)
Pfam (PF17777)
Pfam (PF00428)		Oryctolagus cuniculus (Rabbit)
81CC
(u3)		uL12polymer19521295.61Oryctolagus cuniculus (Rabbit)
82DC
(v3)		mRNApolymer185719.41Oryctolagus cuniculus
83EC
(33)		P/E-Site tRNApolymer7524118.31Oryctolagus cuniculus
84FC
(w3)		Ribosomal proteinpolymer21724879.41UniProt (G1SKZ8)
Pfam (PF00687)		Oryctolagus cuniculus (Rabbit)
85GC
(1)		Sec61Betapolymer151788.01Oryctolagus cuniculus
86HC
(W)		60S ribosomal protein L24-like proteinpolymer13415538.31UniProt (A0A061I3X8)
Pfam (PF01246)		Oryctolagus cuniculus (Rabbit)
87AD, AE, AF, AG, AH...
(51, 81, A2, 33, F2...)		MAGNESIUM IONnon-polymer24.3299Chemie (MG)
88TJ
(51)		BLASTICIDIN Snon-polymer422.41Chemie (BLS)
89AO, BO, CN, CO, DN...
(m3, o3, A2, p3, b2...)		ZINC IONnon-polymer65.48Chemie (ZN)
Sequence modifications
B2: 1 - 295 (UniProt: G1TLT8)
PDBExternal DatabaseDetails
Thr 114Ala 114conflict
C2: 1 - 264 (UniProt: G1SS70)
PDBExternal DatabaseDetails
Gly 236Ser 236conflict
Ala 242Thr 242conflict
G2: 1 - 204 (UniProt: G1TFM5)
PDBExternal DatabaseDetails
Met 0-initiating methionine
H2: 1 - 249 (UniProt: A0A5K1UJS7)
PDBExternal DatabaseDetails
Leu -12-expression tag
Phe -11-expression tag
Arg -10-expression tag
Gly -9-expression tag
Ala -8-expression tag
Ser -7-expression tag
Glu -6-expression tag
Ala -5-expression tag
Val -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Lys 0-expression tag
J2: 2 - 207 (UniProt: G1TJW1)
PDBExternal DatabaseDetails
Arg 47Gly 47variant
M2: 1 - 158 (UniProt: G1TRM4)
PDBExternal DatabaseDetails
Gln 25Leu 25conflict
Ser 29Gly 29conflict
P2: -4 - 151 (UniProt: G1T1F0)
PDBExternal DatabaseDetails
Met -16-initiating methionine
Lys -15-expression tag
Ala -14-expression tag
Arg -13-expression tag
Ala -12-expression tag
Leu -11-expression tag
Ser -10-expression tag
Gly -9-expression tag
Ser -8-expression tag
Gly -7-expression tag
Val -6-expression tag
Arg -5-expression tag
R2: -10 - 146 (UniProt: G1SGX4)
PDBExternal DatabaseDetails
Val -8Glu 18conflict
Glu -7Asp 19conflict
Leu -6Arg 20conflict
Val -5His 21conflict
Leu -4Ser 22conflict
Val -3Ser 23conflict
Leu -2Ala 24conflict
Gly -1Ala 25conflict
U2: 1 - 145 (UniProt: G1TN62)
PDBExternal DatabaseDetails
Gly 119Trp 119conflict
d2: 1 - 69 (UniProt: G1TIB4)
PDBExternal DatabaseDetails
His 5Arg 5conflict
B3: 2 - 403 (UniProt: G1TL06)
PDBExternal DatabaseDetails
Met 1-initiating methionine
C3: 1 - 378 (UniProt: G1SVW5)
PDBExternal DatabaseDetails
Val 379-expression tag
Lys 380-expression tag
Lys 381-expression tag
Pro 382-expression tag
Arg 383-expression tag
Ala 384-expression tag
Val 385-expression tag
Gly 386-expression tag
Ile 387-expression tag
Lys 388-expression tag
Gln 389-expression tag
Lys 390-expression tag
Lys 391-expression tag
Lys 392-expression tag
Pro 393-expression tag
Val 394-expression tag
Val 395-expression tag
Gly 396-expression tag
Arg 397-expression tag
Lys 398-expression tag
Ala 399-expression tag
Ala 400-expression tag
Ala 401-expression tag
Ala 402-expression tag
Lys 403-expression tag
Lys 404-expression tag
Pro 405-expression tag
Ala 406-expression tag
Ala 407-expression tag
Asp 408-expression tag
Lys 409-expression tag
Lys 410-expression tag
Ala 411-expression tag
Ala 412-expression tag
Asp 413-expression tag
Lys 414-expression tag
Arg 415-expression tag
Ala 416-expression tag
Gly 417-expression tag
Pro 418-expression tag
Glu 419-expression tag
Asp 420-expression tag
Lys 421-expression tag
Lys 422-expression tag
Pro 423-expression tag
Ala 424-expression tag
Ala 425-expression tag
D3: 2 - 297 (UniProt: G1SYJ6)
PDBExternal DatabaseDetails
Met 1-initiating methionine
G3: 79 - 319 (UniProt: G1STW0)
PDBExternal DatabaseDetails
Gly 244Cys 167conflict
J3: -2 - 178 (UniProt: G1TUB8)
PDBExternal DatabaseDetails
Gln 0-insertion
Arg 1-insertion
Pro 2-insertion
L3: 1 - 211 (UniProt: G1TKB3)
PDBExternal DatabaseDetails
Arg 74His 74conflict
Arg 190His 190conflict
b3: 1 - 226 (UniProt: G1SGR6)
PDBExternal DatabaseDetails
Ala 227-expression tag
Pro 228-expression tag
Val 229-expression tag
Pro 230-expression tag
Ala 231-expression tag
Gln 232-expression tag
Ala 233-expression tag
Pro 234-expression tag
Pro 235-expression tag
Lys 236-expression tag
Gly 237-expression tag
Ala 238-expression tag
Gln 239-expression tag
Pro 240-expression tag
Pro 241-expression tag
Ala 242-expression tag
Lys 243-expression tag
Ala 244-expression tag
Pro 245-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains86
Total formula weight3504164.6
Non-Polymers*Number of molecules308
Total formula weight8212.9
All*Total formula weight3512377.6
*Water molecules are not included.

247536

PDB entries from 2026-01-14

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