7NWB
CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND INHIBITOR COMPOUND 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Branched-chain-amino-acid aminotransferase, cytosolic | polymer | 389 | 43290.3 | 4 | UniProt (P54687) Pfam (PF01063) | Homo sapiens (Human) | BCAT(c),Protein ECA39, BCAT1 |
| 2 | E, G, I, K (A, B, C, D) | 4-[2,4-bis(oxidanylidene)-6-(trifluoromethyl)-1H-pyrimidin-3-yl]-5-fluoranyl-2-(2-methylphenoxy)benzenecarbonitrile | non-polymer | 405.3 | 4 | Chemie (UTK) | |||
| 3 | F, H, J, L (A, B, C, D) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 4 | Chemie (PLP) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 360 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 386 (UniProt: P54687)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Arg 379 | Ser 379 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 173161.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2609.8 | |
| All* | Total formula weight | 175771.0 |
