7NUP
Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Endoplasmic reticulum aminopeptidase 2 | polymer | 966 | 111425.3 | 4 | UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (Human) | Leukocyte-derived arginine aminopeptidase,L-RAP |
| 2 | E, Q (E, Q) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 3 | F, G, J, K, L... (F, G, J, K, L...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
| 4 | H, I, O, R (H, I, O, R) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 5 | N (N) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 6 | BB, LA, T, TA (D, B, A, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | CB, DB, EB, FB, MA... (D, B, A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 17 | Chemie (NAG) | |||
| 8 | AA, GB, PA, YA (A, D, B, C) | (3~{S})-4-(4-hydroxyphenyl)-~{N}-oxidanyl-3-[5-[[(5-phenylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]butanamide | non-polymer | 513.6 | 4 | Chemie (USK) | |||
| 9 | BA (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 10 | CA, HB, QA (A, D, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 11 | AB, DA, EA, FA, GA... (C, A, D, B) | BROMIDE ION | non-polymer | 79.9 | 13 | Chemie (BR) | |||
| 12 | JB, KB, LB, MB (A, B, C, D) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 960 (UniProt: Q6P179)
| PDB | External Database | Details |
|---|---|---|
| Asn 392 | Lys 392 | variant |
| Arg 961 | - | expression tag |
| His 962 | - | expression tag |
| His 963 | - | expression tag |
| His 964 | - | expression tag |
| His 965 | - | expression tag |
| His 966 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 445701.1 | |
| Branched | Number of molecules | 15 |
| Total formula weight | 8149.6 | |
| Non-Polymers* | Number of molecules | 42 |
| Total formula weight | 7451.7 | |
| All* | Total formula weight | 461302.3 |
