7NSK

Endoplasmic reticulum aminopeptidase 2 complexed with a hydroxamic ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Endoplasmic reticulum aminopeptidase 2	polymer	963	111010.8	2	UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838)	Homo sapiens (Human)	Leukocyte-derived arginine aminopeptidase,L-RAP
2	C, H (C, H)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G22768VO)
3	D, I, J, K, L (D, I, J, K, L)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
4	E, F, G (E, F, G)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)
5	M, Y (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	AA, N, O, P, Q... (B, A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
7	R (A)	1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE	non-polymer		162.2	1	Chemie (P4G)
8	BA, S (B, A)	(2~{S})-3-(4-hydroxyphenyl)-~{N}-oxidanyl-2-[4-[[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]propanamide	non-polymer		500.6	2	Chemie (UQE)
9	T, U, V, W, X (A)	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
10	CA, DA (A, B)	water	water		18.0	40	Chemie (HOH)

Sequence modifications

A, B: 1 - 960 (UniProt: Q6P179)

PDB	External Database	Details
Asn 392	Lys 392	variant
Arg 961	-	expression tag
His 962	-	expression tag
His 963	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	222021.6
Branched	Number of molecules	10
	Total formula weight	5703.3
Non-Polymers*	Number of molecules	16
	Total formula weight	2931.7
All*	Total formula weight	230656.7

*Water molecules are not included.