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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7NRC

Structure of the yeast Gcn1 bound to a leading stalled 80S ribosome with Rbg2, Gir2, A- and P-tRNA and eIF5A

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(S2)		18S rRNA (1771-MER)polymer1800579761.91GenBank (831416132)Saccharomyces cerevisiae S288C
2B
(Sl)		RNA (5'-R(P*AP*UP*GP*AP*AP*A)-3')polymer61923.21Saccharomyces cerevisiae S288C
3C
(SP)		40S ribosomal protein S0-Apolymer20622811.11UniProt (P32905)
Pfam (PF00318)		Saccharomyces cerevisiae S288CNucleic acid-binding protein NAB1A,Small ribosomal subunit protein uS2-A
4D
(SQ)		40S ribosomal protein S1-Apolymer23226314.71UniProt (P33442)
Pfam (PF01015)		Saccharomyces cerevisiae S288CRP10A,Small ribosomal subunit protein eS1-A
5E
(SE)		40S ribosomal protein S15polymer11713265.61UniProt (Q01855)
Pfam (PF00203)		Saccharomyces cerevisiae S288CRIG protein,RP52,S21,Small ribosomal subunit protein uS19,YS21
6F
(SR)		40S ribosomal protein S2polymer21623084.81UniProt (P25443)
Pfam (PF00333)
Pfam (PF03719)		Saccharomyces cerevisiae S288COmnipotent suppressor protein SUP44,RP12,S4,Small ribosomal subunit protein uS5,YS5
7G
(SA)		40S ribosomal protein S3polymer22224631.71UniProt (P05750)
Pfam (PF07650)
Pfam (PF00189)		Saccharomyces cerevisiae S288CRP13,Small ribosomal subunit protein uS3,YS3
8H
(SS)		40S ribosomal protein S4-Apolymer25829167.91UniProt (P0CX35)
Pfam (PF08071)
Pfam (PF01479)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)		Saccharomyces cerevisiae S288CRP5,S7,Small ribosomal subunit protein eS4-A,YS6
9I
(SB)		40S ribosomal protein S5polymer20622908.31UniProt (P26783)
Pfam (PF00177)		Saccharomyces cerevisiae S288CRP14,S2,Small ribosomal subunit protein uS7,YS8
10J
(ST)		40S ribosomal protein S6-Apolymer22826181.41UniProt (P0CX37)
Pfam (PF01092)		Saccharomyces cerevisiae S288CRP9,S10,Small ribosomal subunit protein eS6-A,YS4
11K
(SU)		40S ribosomal protein S7-Apolymer18421000.51UniProt (P26786)
Pfam (PF01251)		Saccharomyces cerevisiae S288CRP30,RP40,Small ribosomal subunit protein eS7-A
12L
(SV)		40S ribosomal protein S8-Apolymer19822277.41UniProt (P0CX39)
Pfam (PF01201)		Saccharomyces cerevisiae S288CRP19,S14,Small ribosomal subunit protein eS8-A,YS9
13M
(SW)		40S ribosomal protein S9-Apolymer18421081.51UniProt (O13516)
Pfam (PF00163)
Pfam (PF01479)		Saccharomyces cerevisiae S288CRP21,S13,Small ribosomal subunit protein uS4-A,YP28,YS11
14N
(SC)		40S ribosomal protein S10-Apolymer9211042.61UniProt (Q08745)
Pfam (PF03501)		Saccharomyces cerevisiae S288CSmall ribosomal subunit protein eS10-A
15O
(SX)		40S ribosomal protein S11-Apolymer14216272.11UniProt (P0CX47)
Pfam (PF16205)
Pfam (PF00366)		Saccharomyces cerevisiae S288CRP41,S18,Small ribosomal subunit protein uS17-A,YS12
16P
(SD)		40S ribosomal protein S12polymer12113028.01UniProt (P48589)
Pfam (PF01248)		Saccharomyces cerevisiae S288CSmall ribosomal subunit protein eS12
17Q
(SY)		40S ribosomal protein S13polymer15016928.71UniProt (P05756)
Pfam (PF08069)
Pfam (PF00312)		Saccharomyces cerevisiae S288CS27a,Small ribosomal subunit protein uS15,YS15
18R
(SZ)		40S ribosomal protein S14-Bpolymer12713446.41UniProt (P39516)
Pfam (PF00411)		Saccharomyces cerevisiae S288CRP59B,Small ribosomal subunit protein uS11-B
19S
(SF)		40S ribosomal protein S16-Apolymer14115659.21UniProt (P0CX51)
Pfam (PF00380)		Saccharomyces cerevisiae S288CRP61R,Small ribosomal subunit protein uS9-A
20T
(SG)		40S ribosomal protein S17-Bpolymer12514268.51UniProt (P14127)
Pfam (PF00833)		Saccharomyces cerevisiae S288CRP51B,Small ribosomal subunit protein eS17-B
21U
(SH)		40S ribosomal protein S18-Apolymer14516940.41UniProt (P0CX55)
Pfam (PF00416)		Saccharomyces cerevisiae S288CSmall ribosomal subunit protein uS13-A
22V
(SI)		40S ribosomal protein S19-Apolymer14315810.91UniProt (P07280)
Pfam (PF01090)		Saccharomyces cerevisiae S288CRP55A,S16a,Small ribosomal subunit protein eS19-A,YP45,YS16A
23W
(SJ)		40S ribosomal protein S20polymer10011363.31UniProt (P38701)
Pfam (PF00338)		Saccharomyces cerevisiae S288CSmall ribosomal subunit protein uS10
24X
(Sa)		40S ribosomal protein S21-Apolymer879758.81UniProt (P0C0V8)
Pfam (PF01249)		Saccharomyces cerevisiae S288CS26,Small ribosomal subunit protein eS21-A,YS25
25Y
(Sb)		40S ribosomal protein S22-Apolymer12914518.91UniProt (P0C0W1)
Pfam (PF00410)		Saccharomyces cerevisiae S288CRP50,S24,Small ribosomal subunit protein uS8-A,YP58,YS22
26Z
(Sc)		40S ribosomal protein S23-Apolymer14415942.71UniProt (P0CX29)
Pfam (PF00164)		Saccharomyces cerevisiae S288CRP37,S28,Small ribosomal subunit protein uS12-A,YS14
27AA
(Sd)		40S ribosomal protein S24-Apolymer13415231.61UniProt (P0CX31)
Pfam (PF01282)		Saccharomyces cerevisiae S288CRP50,Small ribosomal subunit protein eS24-A
28BA
(SK)		40S ribosomal protein S25-Apolymer829540.31UniProt (Q3E792)
Pfam (PF03297)		Saccharomyces cerevisiae S288CRP45,S31,Small ribosomal subunit protein eS25-A,YS23
29CA
(Se)		40S ribosomal protein S26-Bpolymer9711023.01UniProt (P39939)
Pfam (PF01283)		Saccharomyces cerevisiae S288CSmall ribosomal subunit protein eS26-B
30DA
(Sf)		40S ribosomal protein S27-Apolymer818762.21UniProt (P35997)
Pfam (PF01667)		Saccharomyces cerevisiae S288CRP61,Small ribosomal subunit protein eS27-A,YS20
31EA
(SM)		40S ribosomal protein S29-Apolymer536335.31UniProt (P41057)
Pfam (PF00253)		Saccharomyces cerevisiae S288CS36,Small ribosomal subunit protein uS14-A,YS29
32FA
(Sg)		40S ribosomal protein S30-Apolymer576479.71UniProt (P0CX33)
Pfam (PF04758)		Saccharomyces cerevisiae S288CSmall ribosomal subunit protein eS30-A
33GA
(SN)		40S ribosomal protein S31polymer738329.91UniProt (P05759)
Pfam (PF01599)		Saccharomyces cerevisiae S288CCEP76,S37,Small ribosomal subunit protein eS31,YS24
34HA
(SO)		Guanine nucleotide-binding protein subunit beta-like proteinpolymer31234151.51UniProt (P38011)
Pfam (PF00400)		Saccharomyces cerevisiae S288CReceptor for activated C kinase,Receptor of activated protein kinase C 1,RACK1,Small ribosomal subunit protein RACK1
35IA
(SL)		40S ribosomal protein S28-Apolymer637116.31UniProt (Q3E7X9)
Pfam (PF01200)		Saccharomyces cerevisiae S288CS33,Small ribosomal subunit protein eS28-A,YS27
36JA
(Sm)		tRNA (76-MER)polymer7624378.41Saccharomyces cerevisiae S288C
37KA
(Sn)		tRNA (75-MER)polymer7524222.51Saccharomyces cerevisiae S288C
38LA
(So)		Ribosome-interacting GTPase 2polymer36640536.21UniProt (P53295)
Pfam (PF01926)
Pfam (PF16897)
Pfam (PF02824)		Saccharomyces cerevisiae S288CGTP-binding protein RBG2
39MA
(Sp)		GIR2polymer484103.01Saccharomyces cerevisiae S288C
40NA
(LA)		25S rRNA (3184-MER)polymer33941096842.41GenBank (831416132)Saccharomyces cerevisiae S288C
41OA
(LB)		5S rRNA (121-MER)polymer12138951.11Saccharomyces cerevisiae S288C
42PA
(LC)		5.8S rRNA (158-MER)polymer15850682.91Saccharomyces cerevisiae S288C
43QA
(LD)		60S ribosomal protein L2-Apolymer25127089.21UniProt (P0CX45)
Pfam (PF00181)
Pfam (PF03947)		Saccharomyces cerevisiae S288CL5,Large ribosomal subunit protein uL2-A,RP8,YL6
44RA
(LE)		60S ribosomal protein L3polymer38643719.61UniProt (P14126)
Pfam (PF00297)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein uL3,Maintenance of killer protein 8,RP1,Trichodermin resistance protein,YL1
45SA
(LF)		60S ribosomal protein L4-Apolymer36139027.91UniProt (P10664)
Pfam (PF00573)
Pfam (PF14374)		Saccharomyces cerevisiae S288CL2,Large ribosomal subunit protein uL4-A,RP2,YL2
46TA
(LG)		60S ribosomal protein L5polymer29433415.41UniProt (P26321)
Pfam (PF17144)
Pfam (PF14204)		Saccharomyces cerevisiae S288CL1,L1a,Large ribosomal subunit protein uL18,Ribosomal 5S RNA-binding protein,YL3
47UA
(LH)		60S ribosomal protein L6-Bpolymer17519908.41UniProt (P05739)
Pfam (PF01159)		Saccharomyces cerevisiae S288CL17,Large ribosomal subunit protein eL6-B,RP18,YL16
48VA
(LI)		60S ribosomal protein L7-Apolymer22225240.41UniProt (P05737)
Pfam (PF00327)
Pfam (PF08079)		Saccharomyces cerevisiae S288CL6,Large ribosomal subunit protein uL30-A,RP11,YL8
49WA
(LJ)		60S ribosomal protein L8-Apolymer23325815.01UniProt (P17076)
Pfam (PF01248)		Saccharomyces cerevisiae S288CL4,L4-2,L7a-1,Large ribosomal subunit protein eL8-A,Maintenance of killer protein 7,RP6,YL5
50XA
(LK)		60S ribosomal protein L9-Apolymer19121605.11UniProt (P05738)
Pfam (PF00347)		Saccharomyces cerevisiae S288CL8,Large ribosomal subunit protein uL6-A,RP24,YL11
51YA
(LL)		60S ribosomal protein L10polymer21825080.11UniProt (P41805)
Pfam (PF00252)		Saccharomyces cerevisiae S288CL9,Large ribosomal subunit protein uL16,Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein
52ZA
(LM)		60S ribosomal protein L11-Bpolymer16919266.11UniProt (Q3E757)
Pfam (PF00281)
Pfam (PF00673)		Saccharomyces cerevisiae S288CL16,Large ribosomal subunit protein uL5-B,RP39,YL22
53AB
(LN)		60S ribosomal protein L13-Apolymer19321885.21UniProt (Q12690)
Pfam (PF01294)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein eL13-A
54BB
(LO)		60S ribosomal protein L14-Apolymer13614976.81UniProt (P36105)
Pfam (PF00467)
Pfam (PF01929)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein eL14-A
55CB
(LP)		60S ribosomal protein L15-Apolymer20324351.21UniProt (P05748)
Pfam (PF00827)		Saccharomyces cerevisiae S288CL13,Large ribosomal subunit protein eL15-A,RP15R,YL10,YP18
56DB
(LQ)		60S ribosomal protein L16-Apolymer19722029.01UniProt (P26784)
Pfam (PF00572)		Saccharomyces cerevisiae S288CL13a,L21,Large ribosomal subunit protein uL13-A,RP22,YL15
57EB
(LR)		60S ribosomal protein L17-Apolymer18320458.31UniProt (P05740)
Pfam (PF00237)		Saccharomyces cerevisiae S288CL20A,Large ribosomal subunit protein uL22-A,YL17
58FB
(LS)		60S ribosomal protein L18-Apolymer18520478.11UniProt (P0CX49)
Pfam (PF17135)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein eL18-A,RP28
59GB
(LT)		60S ribosomal protein L19-Apolymer18821631.11UniProt (P0CX82)
Pfam (PF01280)		Saccharomyces cerevisiae S288CL23,Large ribosomal subunit protein eL19-A,RP15L,RP33,YL14
60HB
(LU)		60S ribosomal protein L20-Apolymer17120347.71UniProt (P0CX23)
Pfam (PF01775)		Saccharomyces cerevisiae S288CL18a,Large ribosomal subunit protein eL20-A
61IB
(LV)		60S ribosomal protein L21-Apolymer15918148.11UniProt (Q02753)
Pfam (PF01157)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein eL21-A
62JB
(LW)		60S ribosomal protein L22-Apolymer10011263.91UniProt (P05749)
Pfam (PF01776)		Saccharomyces cerevisiae S288CL1c,Large ribosomal subunit protein eL22-A,RP4,YL31
63KB
(LX)		60S ribosomal protein L23-Apolymer13614362.81UniProt (P0CX41)
Pfam (PF00238)		Saccharomyces cerevisiae S288CL17a,Large ribosomal subunit protein uL14-A,YL32
64LB
(LY)		60S ribosomal protein L24-Apolymer657614.91UniProt (P04449)
Pfam (PF01246)		Saccharomyces cerevisiae S288CL30,Large ribosomal subunit protein eL24-A,RP29,YL21
65MB
(LZ)		60S ribosomal protein L25polymer12113771.21UniProt (P04456)
Pfam (PF03939)
Pfam (PF00276)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein uL23,RP16L,YL25,YP42'
66NB
(La)		60S ribosomal protein L26-Apolymer12514005.51UniProt (P05743)
Pfam (PF16906)
Pfam (PF00467)		Saccharomyces cerevisiae S288CL33,Large ribosomal subunit protein uL24-A,YL33
67OB
(Lb)		60S ribosomal protein L27-Apolymer13515437.21UniProt (P0C2H6)
Pfam (PF01777)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein eL27-A
68PB
(Lc)		60S ribosomal protein L28polymer14816630.51UniProt (P02406)
Pfam (PF00828)		Saccharomyces cerevisiae S288CL27a,L29,Large ribosomal subunit protein uL15,RP44,RP62,YL24
69QB
(Ld)		60S ribosomal protein L29polymer586560.71UniProt (P05747)
Pfam (PF01779)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein eL29,YL43
70RB
(Le)		60S ribosomal protein L30polymer9610487.31UniProt (P14120)
Pfam (PF01248)		Saccharomyces cerevisiae S288CL32,Large ribosomal subunit protein eL30,RP73,YL38
71SB
(Lf)		60S ribosomal protein L31-Apolymer10912649.81UniProt (P0C2H8)
Pfam (PF01198)		Saccharomyces cerevisiae S288CL34,Large ribosomal subunit protein eL31-A,YL28
72TB
(Lg)		60S ribosomal protein L32polymer12714478.11UniProt (P38061)
Pfam (PF01655)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein eL32
73UB
(Lh)		60S ribosomal protein L33-Apolymer10612045.91UniProt (P05744)
Pfam (PF01247)		Saccharomyces cerevisiae S288CL37,Large ribosomal subunit protein eL33-A,RP47,YL37
74VB
(Li)		60S ribosomal protein L34-Apolymer11212608.81UniProt (P87262)
Pfam (PF01199)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein eL34-A
75WB
(Lj)		60S ribosomal protein L35-Apolymer11913811.41UniProt (P0CX84)
Pfam (PF00831)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein uL29-A
76XB
(Lk)		60S ribosomal protein L36-Apolymer9911020.11UniProt (P05745)
Pfam (PF01158)		Saccharomyces cerevisiae S288CL39,Large ribosomal subunit protein eL36-A,YL39
77YB
(Ll)		60S ribosomal protein L37-Apolymer819229.61UniProt (P49166)
Pfam (PF01907)		Saccharomyces cerevisiae S288CL43,Large ribosomal subunit protein eL37-A,YL35,YP55
78ZB
(Lm)		60S ribosomal protein L38polymer778714.41UniProt (P49167)
Pfam (PF01781)		Saccharomyces cerevisiae S288CLarge ribosomal subunit protein eL38
79AC
(Ln)		60S ribosomal protein L39polymer506227.41UniProt (P04650)
Pfam (PF00832)		Saccharomyces cerevisiae S288CL46,Large ribosomal subunit protein eL39,YL40
80BC
(Lo)		60S ribosomal protein L40-Apolymer526032.31UniProt (P0CH08)
Pfam (PF01020)		Saccharomyces cerevisiae S288CCEP52,Large ribosomal subunit protein eL40-A
81CC
(Lp)		60S ribosomal protein L41-Apolymer253354.21UniProt (P0CX86)
Pfam (PF05162)		Saccharomyces cerevisiae S288CL47,Large ribosomal subunit protein eL41-A,YL41
82DC
(Lq)		60S ribosomal protein L42-Apolymer10311840.21UniProt (P0CX27)
Pfam (PF00935)		Saccharomyces cerevisiae S288CL41,Large ribosomal subunit protein eL42-A,YL27,YP44
83EC
(Lr)		60S ribosomal protein L43-Apolymer919981.81UniProt (P0CX25)
Pfam (PF01780)		Saccharomyces cerevisiae S288CL37a,Large ribosomal subunit protein eL43-A,YL35
84FC
(Ls)		eiF5Apolymer15416889.01UniProt (P23301)
Pfam (PF21485)
Pfam (PF01287)		Saccharomyces cerevisiae S288C
85GC
(Lt)		L1 60S ribosomal proteinpolymer21017890.01Saccharomyces cerevisiae S288C
86HC
(A)		GCN1polymer120998125.21Saccharomyces cerevisiae S288C
Sequence modifications
SN: 80 - 152 (UniProt: P05759)
PDBExternal DatabaseDetails
Ala 97Lys 97variant
So: 3 - 370 (UniProt: P53295)
PDBExternal DatabaseDetails
Ala 62Lys 60variant
Ala 92Ile 90variant
Glu 94His 92variant
Glu 96Ala 94variant
Lys 134Arg 132variant
Ala 271Thr 269variant
Ala 299Tyr 297variant
Ala 303Arg 301variant
Asp 318Asn 316variant
Glu 361Asp 358variant
LH: 2 - 176 (UniProt: P05739)
PDBExternal DatabaseDetails
Lys 120Asn 120variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains86
Total formula weight3245581.9
All*Total formula weight3245581.9
*Water molecules are not included.

247536

PDB entries from 2026-01-14

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