7NMK
Crystal structure of the heterocyclic toxin methyltransferase from Mycobacterium tuberculosis with bound methylation product 1-methoxyquinolin-4(1H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase | polymer | 245 | 26420.5 | 1 | UniProt (P9WKL5) Pfam (PF13649) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Rv0560c, heterocyclic toxin methyltransferase |
| 2 | B (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 3 | C (A) | 1-methoxy-4-oxoquinoline | non-polymer | 175.2 | 1 | Chemie (UJH) PubChem (54232263) | |||
| 4 | D, E (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 5 | F, G, H, I (A) | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) PubChem (284) | |||
| 6 | J (A) | water | water | 18.0 | 327 | Chemie (HOH) |
Sequence modifications
A: 4 - 227 (UniProt: P9WKL5)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | initiating methionine |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Ser -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Asn -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Tyr -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Gln 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Gly 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26420.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 789.7 | |
| All* | Total formula weight | 27210.2 |
