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7NMK

Crystal structure of the heterocyclic toxin methyltransferase from Mycobacterium tuberculosis with bound methylation product 1-methoxyquinolin-4(1H)-one

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferasepolymer24526420.51UniProt (P9WKL5)
Pfam (PF13649)
In PDB
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Rv0560c, heterocyclic toxin methyltransferase
2AS-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.41Chemie (SAH)
3A1-methoxy-4-oxoquinolinenon-polymer175.21Chemie (UJH)
4ASODIUM IONnon-polymer23.02Chemie (NA)
5AFORMIC ACIDnon-polymer46.04Chemie (FMT)
6waterwater18.0327Chemie (HOH)
Sequence modifications
A: 4 - 227 (UniProt: P9WKL5)
PDBExternal DatabaseDetails
Met -17-initiating methionine
Gly -16-expression tag
Ser -15-expression tag
Ser -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
Glu -5-expression tag
Asn -4-expression tag
Leu -3-expression tag
Tyr -2-expression tag
Phe -1-expression tag
Gln 0-expression tag
Ser 1-expression tag
Ala 2-expression tag
Gly 3-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight26420.5
Non-Polymers*Number of molecules8
Total formula weight789.7
All*Total formula weight27210.2
*Water molecules are not included.

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PDB entries from 2024-06-12

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