7NIC
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(minor class)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interferon-induced helicase C domain-containing protein 1 | polymer | 1025 | 116122.4 | 1 | UniProt (Q8R5F7) Pfam (PF16739) Pfam (PF00619) Pfam (PF04851) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) | Mus musculus (Mouse) | Helicase with 2 CARD domains,Helicard,Interferon induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,RIG-I-like receptor 2,RLR-2 |
| 2 | B (X) | RNA (5'-R(P*GP*UP*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*A)-3') | polymer | 15 | 4894.0 | 1 | synthetic construct | ||
| 3 | C (Y) | RNA (5'-R(P*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*GP*AP*C)-3') | polymer | 15 | 4681.8 | 1 | synthetic construct | ||
| 4 | D (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 5 | E (A) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 1 | Chemie (ALF) | |||
| 6 | F (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 1 - 1025 (UniProt: Q8R5F7)
| PDB | External Database | Details |
|---|---|---|
| Lys 854 | Met 854 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 125698.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 595.6 | |
| All* | Total formula weight | 126293.7 |
