7NHC
1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease ordered (Class2b)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polymerase acidic protein | polymer | 716 | 82707.4 | 1 | UniProt (Q3HM39) Pfam (PF00603) | Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) | RNA-directed RNA polymerase subunit P2 |
| 2 | B (B) | RNA-directed RNA polymerase catalytic subunit | polymer | 757 | 86625.2 | 1 | UniProt (Q3HM40) Pfam (PF00602) | Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) | Polymerase basic protein 1,PB1,RNA-directed RNA polymerase subunit P1 |
| 3 | C (C) | Polymerase basic protein 2,Immunoglobulin G-binding protein A | polymer | 905 | 102377.2 | 1 | UniProt (Q3HM41) UniProt (P38507) Pfam (PF02216) | Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) | RNA-directed RNA polymerase subunit P3,IgG-binding protein A,Staphylococcal protein A,SpA |
| 4 | D (E) | RNA (5'-R(P*GP*GP*CP*CP*UP*GP*CP*U)-3') | polymer | 17 | 5335.1 | 1 | synthetic construct | ||
| 5 | E (D) | RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') | polymer | 15 | 4862.0 | 1 | synthetic construct |
Sequence modifications
C: 1 - 759 (UniProt: Q3HM41)
C: 784 - 897 (UniProt: P38507)
| PDB | External Database | Details |
|---|---|---|
| Glu 760 | - | linker |
| Asn 761 | - | linker |
| Leu 762 | - | linker |
| Tyr 763 | - | linker |
| Phe 764 | - | linker |
| Gln 765 | - | linker |
| Gly 766 | - | linker |
| Glu 767 | - | linker |
| Leu 768 | - | linker |
| Lys 769 | - | linker |
| Thr 770 | - | linker |
| Ala 771 | - | linker |
| Ala 772 | - | linker |
| Leu 773 | - | linker |
| Ala 774 | - | linker |
| Gln 775 | - | linker |
| His 776 | - | linker |
| Asp 777 | - | linker |
| Glu 778 | - | linker |
| Ala 779 | - | linker |
| Val 780 | - | linker |
| Asp 781 | - | linker |
| Asn 782 | - | linker |
| Lys 783 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| His 797 | Asn 171 | conflict |
| Leu 798 | Met 172 | conflict |
| Ala 808 | Gly 182 | conflict |
| Asp 832 | Glu 206 | conflict |
| Ala 833 | Ser 207 | conflict |
| Val 838 | Ala 212 | conflict |
| Ala 866 | Gly 240 | conflict |
| Ala 873 | Asp 247 | conflict |
| Gly 890 | Asp 264 | conflict |
| Val 896 | Ala 270 | conflict |
| Ala 898 | - | expression tag |
| Asn 899 | - | expression tag |
| Ser 900 | - | expression tag |
| Ala 901 | - | expression tag |
| Gly 902 | - | expression tag |
| Lys 903 | - | expression tag |
| Ser 904 | - | expression tag |
| Thr 905 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 281907.0 | |
| All* | Total formula weight | 281907.0 |
