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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7NFX

Mammalian ribosome nascent chain complex with SRP and SRP receptor in early state A

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(1)		SRP RNA 7SLpolymer29996828.31Homo sapiens
2B
(5)		28S ribosomal RNApolymer34931131535.91Oryctolagus cuniculus
3C
(7)		5S ribosomal RNApolymer12038691.91GenBank (4CXE_4)Oryctolagus cuniculus
4D
(8)		5.8S ribosomal RNApolymer15650143.61GenBank (4CXE_3)Oryctolagus cuniculus
5E
(A)		uL2polymer24526701.31Oryctolagus cuniculus
6F
(B)		uL3polymer40346108.01UniProt (G1TL06)
Pfam (PF00297)		Oryctolagus cuniculus (Rabbit)
7G
(C)		60S ribosomal protein L4polymer41346388.91UniProt (G1SVW5)
Pfam (PF00573)
Pfam (PF14374)		Oryctolagus cuniculus (Rabbit)
8H
(D)		60S ribosomal protein L5polymer29734481.81UniProt (G1SYJ6)
UniProt (by SIFTS) (P19949)		Oryctolagus cuniculus (Rabbit)
9I
(E)		60S ribosomal protein L6polymer29133055.31UniProt (G1SKF7)
Pfam (PF03868)
Pfam (PF01159)		Oryctolagus cuniculus (Rabbit)
10J
(F)		uL30polymer22526662.81UniProt (G1SV32)
Pfam (PF08079)
Pfam (PF00327)		Oryctolagus cuniculus (Rabbit)
11K
(G)		60S ribosomal protein L7apolymer31936267.61UniProt (G1STW0)
Pfam (PF01248)		Oryctolagus cuniculus (Rabbit)
12L
(H)		60S ribosomal protein L9polymer19221871.41UniProt (G1SWI6)
Pfam (PF00347)		Oryctolagus cuniculus (Rabbit)
13M
(I)		60S ribosomal protein L10polymer21424643.11UniProt (B7NZQ2)
Pfam (PF00252)		Oryctolagus cuniculus (Rabbit)Ribosomal protein L10 (Predicted)
14N
(J)		Ribosomal protein L11polymer17820288.51UniProt (G1TUB8)
Pfam (PF00281)
Pfam (PF00673)		Oryctolagus cuniculus (Rabbit)
15O
(L)		60S ribosomal protein L13polymer21024216.51UniProt (G1TPV0)Oryctolagus cuniculus (Rabbit)
16P
(M)		60S ribosomal protein L14polymer21823810.41UniProt (U3KNW6)
Pfam (PF01929)
UniProt (by SIFTS) (G1SZ12)		Oryctolagus cuniculus (Rabbit)
17Q
(N)		Ribosomal protein L15polymer20424207.31UniProt (G1T0C1)
Pfam (PF00827)		Oryctolagus cuniculus (Rabbit)
18R
(O)		uL13polymer19923248.91Oryctolagus cuniculus
19S
(P)		uL22polymer15317758.71UniProt (G1TVT6)
Pfam (PF00237)
UniProt (by SIFTS) (G1SCJ6)		Oryctolagus cuniculus (Rabbit)
20T
(Q)		eL18polymer18721457.41UniProt (G1TX70)
Pfam (PF17135)		Oryctolagus cuniculus (Rabbit)
21U
(R)		60S RIBOSOMAL PROTEIN EL19polymer18021613.01UniProt (Q3T0W9)
Pfam (PF01280)		Oryctolagus cuniculus
22V
(S)		eL20polymer17520696.41Oryctolagus cuniculus
23W
(T)		eL21polymer16018610.01UniProt (G1SHQ2)
Pfam (PF01157)		Oryctolagus cuniculus (Rabbit)
24X
(U)		Ribosomal protein L22polymer9911481.21UniProt (G1TSG1)
Pfam (PF01776)		Oryctolagus cuniculus (Rabbit)
25Y
(V)		Ribosomal protein L23polymer14014892.51UniProt (G1T6D1)
Pfam (PF00238)		Oryctolagus cuniculus (Rabbit)
26Z
(W)		Ribosomal protein L24polymer637512.81UniProt (G1SE28)
Pfam (PF01246)		Oryctolagus cuniculus (Rabbit)
27AA
(X)		uL23polymer15617768.21UniProt (G1SE76)
Pfam (PF03939)
Pfam (PF00276)		Oryctolagus cuniculus (Rabbit)
28BA
(Y)		Ribosomal protein L26polymer14517303.41UniProt (G1SQH0)
Pfam (PF16906)
Pfam (PF00467)		Oryctolagus cuniculus (Rabbit)
29CA
(Z)		60S ribosomal protein L27polymer13615835.81UniProt (G1TXF6)
Pfam (PF00467)
Pfam (PF01777)		Oryctolagus cuniculus (Rabbit)
30DA
(a)		uL15polymer14816620.61UniProt (G1SNY0)
Pfam (PF00828)		Oryctolagus cuniculus (Rabbit)
31EA
(b)		60S ribosomal protein L29polymer22324608.21UniProt (G1TN82)
Pfam (PF01779)
UniProt (by SIFTS) (G1SGR6)		Oryctolagus cuniculus (Rabbit)
32FA
(c)		eL30polymer9410496.41Oryctolagus cuniculus
33GA
(d)		eL31polymer12514494.91UniProt (G1SHG0)
Pfam (PF01198)		Oryctolagus cuniculus (Rabbit)
34HA
(e)		eL32polymer12815022.01UniProt (G1TUN8)
Pfam (PF01655)		Oryctolagus cuniculus (Rabbit)
35IA
(f)		eL33polymer11012580.81UniProt (G1SF08)
Pfam (PF01247)		Oryctolagus cuniculus (Rabbit)
36JA
(g)		60S ribosomal protein L34polymer12914557.51UniProt (G1U945)
Pfam (PF01199)
UniProt (by SIFTS) (G1TXG5)		Oryctolagus cuniculus (Rabbit)
37KA
(h)		uL29polymer12314566.61UniProt (G1SIT5)
Pfam (PF00831)		Oryctolagus cuniculus (Rabbit)
38LA
(i)		eL36polymer10412132.61Oryctolagus cuniculus
39MA
(j)		Ribosomal protein L37polymer9711111.01UniProt (U3KPD5)
Pfam (PF01907)		Oryctolagus cuniculus (Rabbit)
40NA
(k)		eL38polymer698107.81Oryctolagus cuniculus
41OA
(l)		eL39polymer516426.81UniProt (G1SYU7)
Pfam (PF00832)		Oryctolagus cuniculus (Rabbit)
42PA
(m)		60S RIBOSOMAL PROTEIN EL40polymer526199.61UniProt (P63048)
Pfam (PF01020)		Oryctolagus cuniculus
43QA
(n)		60s ribosomal protein l41polymer253473.51UniProt (A0A087WNH4)
Pfam (PF05162)		Oryctolagus cuniculus (Rabbit)eL41
44RA
(o)		eL42polymer10512329.81UniProt (A0A5F9D391)
Pfam (PF00935)		Oryctolagus cuniculus (Rabbit)
45SA
(p)		eL43polymer9210299.41UniProt (G1SY53)
Pfam (PF01780)		Oryctolagus cuniculus (Rabbit)
46TA
(q)		Signal recognition particle 19 kDa proteinpolymer14416183.71UniProt (P09132)
Pfam (PF01922)		Homo sapiens (Human)SRP19
47UA
(r)		eL28polymer13715783.61UniProt (G1U7L1)
Pfam (PF01778)		Oryctolagus cuniculus (Rabbit)
48VA
(s)		Signal Sequencepolymer211805.21Homo sapiens
49WA
(t)		Signal recognition particle 14 kDa proteinpolymer13614596.01UniProt (P37108)
Pfam (PF02290)		Homo sapiens (Human)SRP14,18 kDa Alu RNA-binding protein
50XA
(u)		Signal recognition particle subunit SRP68polymer62770831.61UniProt (Q9UHB9)
Pfam (PF16969)		Homo sapiens (Human)SRP68,Signal recognition particle 68 kDa protein
51YA
(v)		Signal recognition particle receptor subunit betapolymer27129737.21UniProt (Q9Y5M8)
Pfam (PF09439)		Homo sapiens (Human)SR-beta,Protein APMCF1
52ZA
(w)		Signal recognition particle 9 kDa proteinpolymer8610127.81UniProt (P49458)
Pfam (PF05486)		Homo sapiens (Human)SRP9
53AB
(x)		Signal recognition particle 54 kDa proteinpolymer50455847.71UniProt (P61011)
Pfam (PF02881)
Pfam (PF00448)
Pfam (PF02978)		Homo sapiens (Human)SRP54
54BB
(y)		Signal recognition particle receptor subunit alphapolymer63869908.11UniProt (P08240)
Pfam (PF04086)
Pfam (PF02881)
Pfam (PF00448)		Homo sapiens (Human)SR-alpha,Docking protein alpha,DP-alpha
55CB
(z)		Signal recognition particle subunit SRP72polymer67174720.31UniProt (O76094)
Pfam (PF17004)
Pfam (PF13181)
Pfam (PF08492)		Homo sapiens (Human)SRP72,Signal recognition particle 72 kDa protein
56DB, EB, FB, GB, HB
(g, j, m, o, p)		ZINC IONnon-polymer65.45Chemie (ZN)
57IB, LB
(v, x)		MAGNESIUM IONnon-polymer24.32Chemie (MG)
58JB
(v)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
59KB
(x)		PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTERnon-polymer522.21Chemie (GNP)
Sequence modifications
B: 2 - 403 (UniProt: G1TL06)
PDBExternal DatabaseDetails
Met 1-initiating methionine
D: 2 - 297 (UniProt: G1SYJ6)
PDBExternal DatabaseDetails
Met 1-initiating methionine
E: -5 - 284 (UniProt: G1SKF7)
PDBExternal DatabaseDetails
Arg 126Lys 133conflict
Gln 217Lys 224conflict
F: 26 - 250 (UniProt: G1SV32)
PDBExternal DatabaseDetails
Ala 175Thr 174conflict
Gly 185Asn 184conflict
Arg 202His 201conflict
Glu 233Gly 232conflict
L: 2 - 211 (UniProt: G1TPV0)
PDBExternal DatabaseDetails
Ala 47-insertion
Pro 48-insertion
Arg 49-insertion
Pro 50-insertion
Ala 51-insertion
Ser 52-insertion
Gly 53-insertion
Pro 54-insertion
Leu 55-insertion
Q: 2 - 188 (UniProt: G1TX70)
PDBExternal DatabaseDetails
Arg 6Leu 6conflict
Arg 14Trp 14conflict
Ile 23Met 23conflict
Tyr 24Cys 24conflict
Arg 38His 38conflict
Asn 57Lys 57conflict
Met 66Val 66conflict
Gly 74Asp 74conflict
Arg 75Pro 75conflict
Gly 77Asn 77conflict
Ser 106Thr 106conflict
Arg 110His 110conflict
Gly 117Glu 117conflict
Asp 124His 124conflict
Cys 134Arg 134conflict
Arg 150Gln 150conflict
Arg 172Gly 172conflict
Arg 184Trp 184conflict
U: 17 - 115 (UniProt: G1TSG1)
PDBExternal DatabaseDetails
Gly 32Arg 32variant
Ala 36Glu 36variant
Phe 39Ser 39variant
Gly 54Arg 54variant
Val 60Ala 60variant
Arg 97His 97variant
a: 2 - 148 (UniProt: G1SNY0)
PDBExternal DatabaseDetails
Met 1-initiating methionine
x: 1 - 504 (UniProt: P61011)
PDBExternal DatabaseDetails
Glu 226Gly 226engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains55
Total formula weight2466649.5
Non-Polymers*Number of molecules9
Total formula weight1421.0
All*Total formula weight2468070.5
*Water molecules are not included.

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PDB entries from 2025-06-11

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