7NFB

ER-PRS*(+) (Y537S) in complex with genistein and SRC-2 coactivator peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Estrogen receptor	polymer	247	28380.3	2	UniProt (P03372) Pfam (PF00104)	Homo sapiens (Human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	C, D (C, D)	Nuclear receptor coactivator 2	polymer	15	1693.0	2	UniProt (Q15596)	Homo sapiens	NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2
3	E, P (A, B)	GENISTEIN	non-polymer		270.2	2	Chemie (GEN)
4	F, G, Q (A, B)	SODIUM ION	non-polymer		23.0	3	Chemie (NA)
5	H, I, J, K, L... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	16	Chemie (EDO)
6	AA, BA, O (B, A)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
7	CA (C)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
8	DA, EA, FA, GA (A, B, C, D)	water	water		18.0	435	Chemie (HOH)

Sequence modifications

A, B: 304 - 548 (UniProt: P03372)

PDB	External Database	Details
Ser 302	-	expression tag
Met 303	-	expression tag
Ile 315	Met 315	engineered mutation
Ile 316	Val 316	engineered mutation
Glu 321	Asp 321	engineered mutation
Ser 334	Thr 334	engineered mutation
Tyr 341	Ser 341	engineered mutation
Lys 363	Arg 363	engineered mutation
Ser 371	Thr 371	engineered mutation
Ser 381	Cys 381	engineered mutation
Asp 397	Glu 397	engineered mutation
Asp 407	Asn 407	engineered mutation
Glu 413	Asn 413	engineered mutation
Ser 417	Cys 417	engineered mutation
Glu 433	Ser 433	engineered mutation
Glu 437	Met 437	engineered mutation
Lys 439	Asn 439	engineered mutation
Arg 442	Gly 442	engineered mutation
Ala 450	Ser 450	engineered mutation
Asn 471	Glu 471	engineered mutation
Glu 473	Asp 473	engineered mutation
Lys 474	His 474	engineered mutation
Met 478	Val 478	engineered mutation
Ala 485	Thr 485	engineered mutation
Trp 488	His 488	engineered mutation
Tyr 489	Leu 489	engineered mutation
Ser 493	Ala 493	engineered mutation
Ser 496	Thr 496	engineered mutation
Ser 530	Cys 530	engineered mutation
Ser 537	Tyr 537	engineered mutation

C, D: 686 - 699 (UniProt: Q15596)

PDB	External Database	Details
Ace 685	-	acetylation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	60146.6
Non-Polymers*	Number of molecules	25
	Total formula weight	1801.0
All*	Total formula weight	61947.5

*Water molecules are not included.