7NEZ
Structure of topotecan-bound ABCG2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ATP-binding cassette sub-family G member 2 | polymer | 655 | 72385.9 | 2 | UniProt (Q9UNQ0) Pfam (PF00005) Pfam (PF19055) Pfam (PF01061) | Homo sapiens (human) | Breast cancer resistance protein,CDw338,Mitoxantrone resistance-associated protein,Placenta-specific ATP-binding cassette transporter,Urate exporter |
| 2 | C, E (C, E) | 5D3(Fab) light chain variable domain | polymer | 214 | 23594.0 | 2 | Mus musculus | ||
| 3 | D, F (D, F) | 5D3(Fab) heavy chain variable domain | polymer | 221 | 23843.6 | 2 | Mus musculus | ||
| 4 | G (A) | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE | non-polymer | 421.4 | 1 | Chemie (TTC) | |||
| 5 | H, I, J, K (A, B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 239647.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1306.3 | |
| All* | Total formula weight | 240953.3 |
