7NEL
ER-PRS*(+) (Y537S) in complex with estradiol and SRC-2 coactivator peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Estrogen receptor | polymer | 247 | 28380.3 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | C, D | Nuclear receptor coactivator 2 | polymer | 15 | 1693.0 | 2 | UniProt (Q15596) In PDB | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
3 | A, B | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) | |||
4 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
6 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
7 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
8 | water | water | 18.0 | 429 | Chemie (HOH) |
Sequence modifications
A, B: 304 - 548 (UniProt: P03372)
C, D: 686 - 699 (UniProt: Q15596)
PDB | External Database | Details |
---|---|---|
Ser 302 | - | expression tag |
Met 303 | - | expression tag |
Ile 315 | Met 315 | engineered mutation |
Ile 316 | Val 316 | engineered mutation |
Glu 321 | Asp 321 | engineered mutation |
Ser 334 | Thr 334 | engineered mutation |
Tyr 341 | Ser 341 | engineered mutation |
Lys 363 | Arg 363 | engineered mutation |
Ser 371 | Thr 371 | engineered mutation |
Ser 381 | Cys 381 | engineered mutation |
Asp 397 | Glu 397 | engineered mutation |
Asp 407 | Asn 407 | engineered mutation |
Glu 413 | Asn 413 | engineered mutation |
Ser 417 | Cys 417 | engineered mutation |
Glu 433 | Ser 433 | engineered mutation |
Glu 437 | Met 437 | engineered mutation |
Lys 439 | Asn 439 | engineered mutation |
Arg 442 | Gly 442 | engineered mutation |
Ala 450 | Ser 450 | engineered mutation |
Asn 471 | Glu 471 | engineered mutation |
Glu 473 | Asp 473 | engineered mutation |
Lys 474 | His 474 | engineered mutation |
Met 478 | Val 478 | engineered mutation |
Ala 485 | Thr 485 | engineered mutation |
Trp 488 | His 488 | engineered mutation |
Tyr 489 | Leu 489 | engineered mutation |
Ser 493 | Ala 493 | engineered mutation |
Ser 496 | Thr 496 | engineered mutation |
Ser 530 | Cys 530 | engineered mutation |
Ser 537 | Tyr 537 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ace 685 | - | acetylation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 60146.6 | |
Non-Polymers* | Number of molecules | 23 |
Total formula weight | 1932.6 | |
All* | Total formula weight | 62079.2 |