7NEH
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-269 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | COVOX-269 Fab heavy chain | polymer | 222 | 23557.4 | 1 | Homo sapiens (Human) | ||
| 2 | B (L) | COVOX-269 fab light chain | polymer | 215 | 23300.0 | 1 | Homo sapiens (Human) | ||
| 3 | C (E) | Spike glycoprotein | polymer | 205 | 23150.9 | 1 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | S glycoprotein,E2,Peplomer protein |
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 5 | AA, BA, E, F, G... (E, H, L) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 19 | Chemie (EDO) | |||
| 6 | H, O, Y (H, L, E) | NITRATE ION | non-polymer | 62.0 | 3 | Chemie (NO3) | |||
| 7 | P (L) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | T (L) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 9 | CA (E) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 10 | DA, EA, FA (H, L, E) | water | water | 18.0 | 496 | Chemie (HOH) |
Sequence modifications
E: 333 - 528 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Glu 324 | - | expression tag |
| Thr 325 | - | expression tag |
| Gly 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| Lys 527 | Pro 527 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70008.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 1602.9 | |
| All* | Total formula weight | 72181.8 |
