7NEC
ROR(gamma)t ligand binding domain in complex with allosteric ligand FM217
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Nuclear receptor ROR-gamma | polymer | 247 | 28756.3 | 1 | UniProt (P51449) Pfam (PF00104) In PDB | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | A | 4-[[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-2-yl)-1,2-oxazol-4-yl]methoxy]benzoic acid | non-polymer | 462.8 | 1 | Chemie (U95) | |||
| 3 | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A: 265 - 507 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 261 | - | expression tag |
| Ser 262 | - | expression tag |
| His 263 | - | expression tag |
| Met 264 | - | expression tag |
| His 455 | Cys 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28756.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 462.8 | |
| All* | Total formula weight | 29219.1 |
