7NDT

UL40:01 TCR in complex with HLA-E with a non-natural amino acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (AAA, FFF)	HLA class I histocompatibility antigen, alpha chain E	polymer	277	31911.2	2	UniProt (P13747) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (human)	MHC class I antigen E
2	B, G (BBB, GGG)	Beta-2-microglobulin	polymer	100	11879.4	2	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)
3	C, H (CCC, HHH)	UL40(15-23 H4C)	polymer	9	1046.4	2		Homo sapiens
4	D, I (DDD, III)	T cell receptor alpha variable 26-1,T cell receptor alpha joining 37,T cell receptor alpha chain constant	polymer	198	22012.5	2	UniProt (A0A087WT03) UniProt (A0A087X096) UniProt (P01848) Pfam (PF07686) Pfam (PF09291)	Homo sapiens (human)
5	E, J (EEE, JJJ)	T cell receptor beta variable 14,T cell receptor beta joining 2-3,T cell receptor beta constant 2	polymer	243	27613.8	2	UniProt (A0A5B0) UniProt (A0A0B4J200) UniProt (A0A5B9) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (human)
6	K, L, M (EEE, FFF, III)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

AAA, FFF: 1 - 280 (UniProt: P13747)

PDB	External Database	Details
Met 0	-	initiating methionine
Cys 116	Phe 137	conflict

BBB, GGG: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

DDD, III: 2 - 106 (UniProt: A0A087WT03)

DDD, III: 109 - 128 (UniProt: A0A087X096)

PDB	External Database	Details
Asp 129	-	linker

DDD, III: 130 - 214 (UniProt: P01848)

PDB	External Database	Details
Cys 176	Thr 47	engineered mutation

EEE, JJJ: 1 - 108 (UniProt: A0A5B0)

EEE, JJJ: 114 - 127 (UniProt: A0A0B4J200)

PDB	External Database	Details
Glu 129	-	linker

EEE, JJJ: 130 - 258 (UniProt: A0A5B9)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.