7NBH

Crystal structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (AAA, BBB, CCC, DDD)	Serine racemase	polymer	346	37684.0	4	UniProt (Q9GZT4) Pfam (PF00291)	Homo sapiens (Human)	D-serine ammonia-lyase,D-serine dehydratase,L-serine ammonia-lyase,L-serine dehydratase
2	CA, DA, E, EA, GA... (CCC, AAA, DDD, BBB)	1,2-ETHANEDIOL	non-polymer		62.1	16	Chemie (EDO)
3	F, H, IA, JA, MA... (AAA, CCC, DDD, BBB)	SODIUM ION	non-polymer		23.0	9	Chemie (NA)
4	BA, G, OA, V (CCC, AAA, DDD, BBB)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
5	AA, FA, HA, M, N... (CCC, AAA, DDD)	GLYCEROL	non-polymer		92.1	7	Chemie (GOL)
6	Q, R, WA, X, XA... (AAA, DDD, BBB)	N-[(1H-benzimidazol-2-yl)methyl]furan-2-carboxamide	non-polymer		241.2	6	Chemie (W0D)
7	KA, YA (CCC, DDD)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
8	LA (CCC)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
9	TA, VA (DDD)	TRIETHYLENE GLYCOL	non-polymer		150.2	2	Chemie (PGE)
10	AB, BB, CB, ZA (BBB, CCC, DDD, AAA)	water	water		18.0	975	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD: 1 - 340 (UniProt: Q9GZT4)

PDB	External Database	Details
Asp 2	Cys 2	engineered mutation
Asp 6	Cys 6	engineered mutation
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	150735.9
Non-Polymers*	Number of molecules	47
	Total formula weight	3836.8
All*	Total formula weight	154572.8

*Water molecules are not included.