7NBG

Crystal structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (AAA, BBB, CCC, DDD)	Serine racemase	polymer	346	37455.9	4	UniProt (Q9GZT4) Pfam (PF00291)	Homo sapiens (Human)	D-serine ammonia-lyase,D-serine dehydratase,L-serine ammonia-lyase,L-serine dehydratase
2	E, KA, S, Z (AAA, DDD, BBB, CCC)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	4	Chemie (PLP)
3	CA, DA, EA, F, GA... (CCC, AAA, DDD, BBB)	1,2-ETHANEDIOL	non-polymer		62.1	14	Chemie (EDO)
4	G, I, IA, JA, LA... (AAA, CCC, DDD, BBB)	SODIUM ION	non-polymer		23.0	9	Chemie (NA)
5	BA, H, MA, U (CCC, AAA, DDD, BBB)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	AA, FA, HA, N, Q... (CCC, AAA, DDD)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
7	P, X (AAA, BBB)	~{N}-[2-(2-methylphenyl)ethyl]ethanamide	non-polymer		177.2	2	Chemie (U78)
8	VA, Y (DDD, BBB)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
9	NA (DDD)	2-(2-METHOXYETHOXY)ETHANOL	non-polymer		120.1	1	Chemie (PG0)
10	SA (DDD)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
11	TA (DDD)	ORTHO-XYLENE	non-polymer		106.2	1	Chemie (OXE)
12	WA, XA, YA, ZA (AAA, BBB, CCC, DDD)	water	water		18.0	941	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD: 1 - 340 (UniProt: Q9GZT4)

PDB	External Database	Details
Asp 2	Cys 2	engineered mutation
Asp 6	Cys 6	engineered mutation
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	149823.5
Non-Polymers*	Number of molecules	44
	Total formula weight	3556.9
All*	Total formula weight	153380.3

*Water molecules are not included.