7NBD

Crystal structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (AAA, BBB, CCC, DDD)	Serine racemase	polymer	346	37455.9	4	UniProt (Q9GZT4) Pfam (PF00291)	Homo sapiens (Human)	D-serine ammonia-lyase,D-serine dehydratase,L-serine ammonia-lyase,L-serine dehydratase
2	AA, E, N, U (DDD, AAA, BBB, CCC)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	4	Chemie (PLP)
3	F, G, H, L, M... (AAA, BBB, CCC)	GLYCEROL	non-polymer		92.1	8	Chemie (GOL)
4	BA, DA, I, Q, R... (DDD, AAA, BBB, CCC)	CALCIUM ION	non-polymer		40.1	7	Chemie (CA)
5	CA, J (DDD, AAA)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	K, T (AAA, BBB)	[4-(1H-benzimidazol-1-yl)phenyl]methanol	non-polymer		224.3	2	Chemie (JFS)
7	FA, S, Z (DDD, BBB, CCC)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
8	V (CCC)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
9	EA (DDD)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
10	GA, HA, IA, JA (AAA, BBB, CCC, DDD)	water	water		18.0	1053	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD: 1 - 340 (UniProt: Q9GZT4)

PDB	External Database	Details
Asp 2	Cys 2	engineered mutation
Asp 6	Cys 6	engineered mutation
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	149823.5
Non-Polymers*	Number of molecules	28
	Total formula weight	2862.4
All*	Total formula weight	152685.8

*Water molecules are not included.