7NAK

Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (TIR:1AD)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (D, C, G, B, A...)	NAD(+) hydrolase SARM1	polymer	697	76471.5	8	UniProt (Q6SZW1) Pfam (PF07647) Pfam (PF13676)	Homo sapiens (Human)	hSARM1,NADP(+) hydrolase SARM1,Sterile alpha and Armadillo repeat protein,Sterile alpha and TIR motif-containing protein 1,Sterile alpha motif domain-containing protein 2,SAM domain-containing protein 2,Tir-1 homolog,HsTIR
2	I, J, K, L, M... (D, C, G, B, A...)	[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate	non-polymer		797.4	8	Chemie (1QD)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	611771.8
Non-Polymers*	Number of molecules	8
	Total formula weight	6378.9
All*	Total formula weight	618150.7

*Water molecules are not included.