7NA1
HDM2 in complex with compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase Mdm2 | polymer | 109 | 12526.3 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | C, F (A, B) | 8-(1-benzothiophen-5-yl)-7-[(4-chlorophenyl)methyl]-6-{[(1R)-1-cyclopropylethyl]amino}-7H-purine-2-carboxylic acid | non-polymer | 504.0 | 2 | Chemie (1GI) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 5 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 125 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Tyr 55 | Phe 61 | engineered mutation |
| His 76 | Tyr 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25052.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1388.3 | |
| All* | Total formula weight | 26440.9 |
