7NA1
HDM2 in complex with compound 2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | E3 ubiquitin-protein ligase Mdm2 | polymer | 109 | 12526.3 | 2 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
2 | A, B | 8-(1-benzothiophen-5-yl)-7-[(4-chlorophenyl)methyl]-6-{[(1R)-1-cyclopropylethyl]amino}-7H-purine-2-carboxylic acid | non-polymer | 504.0 | 2 | Chemie (1GI) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
4 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
5 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 125 (UniProt: Q00987)
PDB | External Database | Details |
---|---|---|
Tyr 55 | Phe 61 | engineered mutation |
His 76 | Tyr 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 25052.6 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1388.3 | |
All* | Total formula weight | 26440.9 |