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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7N9E

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB34

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(D)		Nb34 nanobodypolymer15516951.61Lama glama
2B, C, D
(A, B, C)		Spike glycoproteinpolymer1380152312.83UniProt (P0DTC2)
Pfam (PF16451)
Pfam (PF09408)
Pfam (PF19209)
Pfam (PF01601)		Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2 COVID-19 virus)S glycoprotein,E2,Peplomer protein
Sequence modifications
A, B, C: 1 - 1208 (UniProt: P0DTC2)
PDBExternal DatabaseDetails
Met -91-initiating methionine
Gly -90-expression tag
Gly -89-expression tag
Glu -88-expression tag
Gly -87-expression tag
Leu -86-expression tag
Arg -85-expression tag
Ala -84-expression tag
Ser -83-expression tag
Pro -82-expression tag
Arg -81-expression tag
Arg -80-expression tag
Arg -79-expression tag
Pro -78-expression tag
Leu -77-expression tag
Leu -76-expression tag
Pro -75-expression tag
Leu -74-expression tag
Gln -73-expression tag
Pro -72-expression tag
Arg -71-expression tag
Gly -70-expression tag
Cys -69-expression tag
Pro -68-expression tag
Arg -67-expression tag
Gly -66-expression tag
Asp -65-expression tag
Gly -64-expression tag
Cys -63-expression tag
Leu -62-expression tag
Arg -61-expression tag
Gly -60-expression tag
Gly -59-expression tag
Arg -58-expression tag
Gly -57-expression tag
Arg -56-expression tag
Ala -55-expression tag
Gly -54-expression tag
Phe -53-expression tag
Gly -52-expression tag
Phe -51-expression tag
Trp -50-expression tag
Arg -49-expression tag
Val -48-expression tag
Thr -47-expression tag
Gly -46-expression tag
Gly -45-expression tag
Ser -44-expression tag
Ser -43-expression tag
Ala -42-expression tag
Ser -41-expression tag
Ala -40-expression tag
Asn -39-expression tag
His -38-expression tag
Val -37-expression tag
His -36-expression tag
Ala -35-expression tag
Phe -34-expression tag
Phe -33-expression tag
Phe -32-expression tag
Phe -31-expression tag
Leu -30-expression tag
Gln -29-expression tag
Leu -28-expression tag
Leu -27-expression tag
Gly -26-expression tag
Asn -25-expression tag
Val -24-expression tag
Leu -23-expression tag
Val -22-expression tag
Val -21-expression tag
Val -20-expression tag
Leu -19-expression tag
Ser -18-expression tag
His -17-expression tag
His -16-expression tag
Phe -15-expression tag
Gly -14-expression tag
Lys -13-expression tag
Glu -12-expression tag
Leu -11-expression tag
Arg -10-expression tag
Pro -9-expression tag
Ser -8-expression tag
Gln -7-expression tag
Ala -6-expression tag
Glu -5-expression tag
Phe -4-expression tag
Gly -3-expression tag
Thr -2-expression tag
Ala -1-expression tag
Thr 0-expression tag
Gly 682Arg 682engineered mutation
Ser 683Arg 683engineered mutation
Ser 685Arg 685engineered mutation
Pro 817Phe 817engineered mutation
Pro 892Ala 892engineered mutation
Pro 899Ala 899engineered mutation
Pro 942Ala 942engineered mutation
Pro 986Lys 986engineered mutation
Pro 987Val 987engineered mutation
Gly 1209-expression tag
Ser 1210-expression tag
Gly 1211-expression tag
Tyr 1212-expression tag
Ile 1213-expression tag
Pro 1214-expression tag
Glu 1215-expression tag
Ala 1216-expression tag
Pro 1217-expression tag
Arg 1218-expression tag
Asp 1219-expression tag
Gly 1220-expression tag
Gln 1221-expression tag
Ala 1222-expression tag
Tyr 1223-expression tag
Val 1224-expression tag
Arg 1225-expression tag
Lys 1226-expression tag
Asp 1227-expression tag
Gly 1228-expression tag
Glu 1229-expression tag
Trp 1230-expression tag
Val 1231-expression tag
Leu 1232-expression tag
Leu 1233-expression tag
Ser 1234-expression tag
Thr 1235-expression tag
Phe 1236-expression tag
Leu 1237-expression tag
Gly 1238-expression tag
Arg 1239-expression tag
Ser 1240-expression tag
Leu 1241-expression tag
Glu 1242-expression tag
Val 1243-expression tag
Leu 1244-expression tag
Phe 1245-expression tag
Gln 1246-expression tag
Gly 1247-expression tag
Pro 1248-expression tag
Gly 1249-expression tag
His 1250-expression tag
His 1251-expression tag
His 1252-expression tag
His 1253-expression tag
His 1254-expression tag
His 1255-expression tag
His 1256-expression tag
His 1257-expression tag
Ser 1258-expression tag
Ala 1259-expression tag
Trp 1260-expression tag
Ser 1261-expression tag
His 1262-expression tag
Pro 1263-expression tag
Gln 1264-expression tag
Phe 1265-expression tag
Glu 1266-expression tag
Lys 1267-expression tag
Gly 1268-expression tag
Gly 1269-expression tag
Gly 1270-expression tag
Ser 1271-expression tag
Gly 1272-expression tag
Gly 1273-expression tag
Gly 1274-expression tag
Gly 1275-expression tag
Ser 1276-expression tag
Gly 1277-expression tag
Gly 1278-expression tag
Ser 1279-expression tag
Ala 1280-expression tag
Trp 1281-expression tag
Ser 1282-expression tag
His 1283-expression tag
Pro 1284-expression tag
Gln 1285-expression tag
Phe 1286-expression tag
Glu 1287-expression tag
Lys 1288-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight473889.9
All*Total formula weight473889.9
*Water molecules are not included.

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PDB entries from 2024-10-30

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