7N9B
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB21
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Spike glycoprotein | polymer | 1380 | 152312.8 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2 COVID-19 virus) | S glycoprotein,E2,Peplomer protein |
2 | D, F | NB21 Nanobody | polymer | 146 | 15770.6 | 2 | Lama glama |
Sequence modifications
A, B, C: 93 - 1300 (UniProt: P0DTC2)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Gly 2 | - | expression tag |
Gly 3 | - | expression tag |
Glu 4 | - | expression tag |
Gly 5 | - | expression tag |
Leu 6 | - | expression tag |
Arg 7 | - | expression tag |
Ala 8 | - | expression tag |
Ser 9 | - | expression tag |
Pro 10 | - | expression tag |
Arg 11 | - | expression tag |
Arg 12 | - | expression tag |
Arg 13 | - | expression tag |
Pro 14 | - | expression tag |
Leu 15 | - | expression tag |
Leu 16 | - | expression tag |
Pro 17 | - | expression tag |
Leu 18 | - | expression tag |
Gln 19 | - | expression tag |
Pro 20 | - | expression tag |
Arg 21 | - | expression tag |
Gly 22 | - | expression tag |
Cys 23 | - | expression tag |
Pro 24 | - | expression tag |
Arg 25 | - | expression tag |
Gly 26 | - | expression tag |
Asp 27 | - | expression tag |
Gly 28 | - | expression tag |
Cys 29 | - | expression tag |
Leu 30 | - | expression tag |
Arg 31 | - | expression tag |
Gly 32 | - | expression tag |
Gly 33 | - | expression tag |
Arg 34 | - | expression tag |
Gly 35 | - | expression tag |
Arg 36 | - | expression tag |
Ala 37 | - | expression tag |
Gly 38 | - | expression tag |
Phe 39 | - | expression tag |
Gly 40 | - | expression tag |
Phe 41 | - | expression tag |
Trp 42 | - | expression tag |
Arg 43 | - | expression tag |
Val 44 | - | expression tag |
Thr 45 | - | expression tag |
Gly 46 | - | expression tag |
Gly 47 | - | expression tag |
Ser 48 | - | expression tag |
Ser 49 | - | expression tag |
Ala 50 | - | expression tag |
Ser 51 | - | expression tag |
Ala 52 | - | expression tag |
Asn 53 | - | expression tag |
His 54 | - | expression tag |
Val 55 | - | expression tag |
His 56 | - | expression tag |
Ala 57 | - | expression tag |
Phe 58 | - | expression tag |
Phe 59 | - | expression tag |
Phe 60 | - | expression tag |
Phe 61 | - | expression tag |
Leu 62 | - | expression tag |
Gln 63 | - | expression tag |
Leu 64 | - | expression tag |
Leu 65 | - | expression tag |
Gly 66 | - | expression tag |
Asn 67 | - | expression tag |
Val 68 | - | expression tag |
Leu 69 | - | expression tag |
Val 70 | - | expression tag |
Val 71 | - | expression tag |
Val 72 | - | expression tag |
Leu 73 | - | expression tag |
Ser 74 | - | expression tag |
His 75 | - | expression tag |
His 76 | - | expression tag |
Phe 77 | - | expression tag |
Gly 78 | - | expression tag |
Lys 79 | - | expression tag |
Glu 80 | - | expression tag |
Leu 81 | - | expression tag |
Arg 82 | - | expression tag |
Pro 83 | - | expression tag |
Ser 84 | - | expression tag |
Gln 85 | - | expression tag |
Ala 86 | - | expression tag |
Glu 87 | - | expression tag |
Phe 88 | - | expression tag |
Gly 89 | - | expression tag |
Thr 90 | - | expression tag |
Ala 91 | - | expression tag |
Thr 92 | - | expression tag |
Gly 774 | Arg 682 | engineered mutation |
Ser 775 | Arg 683 | engineered mutation |
Ser 777 | Arg 685 | engineered mutation |
Pro 909 | Phe 817 | engineered mutation |
Pro 984 | Ala 892 | engineered mutation |
Pro 991 | Ala 899 | engineered mutation |
Pro 1034 | Ala 942 | engineered mutation |
Pro 1078 | Lys 986 | engineered mutation |
Pro 1079 | Val 987 | engineered mutation |
Gly 1301 | - | expression tag |
Ser 1302 | - | expression tag |
Gly 1303 | - | expression tag |
Tyr 1304 | - | expression tag |
Ile 1305 | - | expression tag |
Pro 1306 | - | expression tag |
Glu 1307 | - | expression tag |
Ala 1308 | - | expression tag |
Pro 1309 | - | expression tag |
Arg 1310 | - | expression tag |
Asp 1311 | - | expression tag |
Gly 1312 | - | expression tag |
Gln 1313 | - | expression tag |
Ala 1314 | - | expression tag |
Tyr 1315 | - | expression tag |
Val 1316 | - | expression tag |
Arg 1317 | - | expression tag |
Lys 1318 | - | expression tag |
Asp 1319 | - | expression tag |
Gly 1320 | - | expression tag |
Glu 1321 | - | expression tag |
Trp 1322 | - | expression tag |
Val 1323 | - | expression tag |
Leu 1324 | - | expression tag |
Leu 1325 | - | expression tag |
Ser 1326 | - | expression tag |
Thr 1327 | - | expression tag |
Phe 1328 | - | expression tag |
Leu 1329 | - | expression tag |
Gly 1330 | - | expression tag |
Arg 1331 | - | expression tag |
Ser 1332 | - | expression tag |
Leu 1333 | - | expression tag |
Glu 1334 | - | expression tag |
Val 1335 | - | expression tag |
Leu 1336 | - | expression tag |
Phe 1337 | - | expression tag |
Gln 1338 | - | expression tag |
Gly 1339 | - | expression tag |
Pro 1340 | - | expression tag |
Gly 1341 | - | expression tag |
His 1342 | - | expression tag |
His 1343 | - | expression tag |
His 1344 | - | expression tag |
His 1345 | - | expression tag |
His 1346 | - | expression tag |
His 1347 | - | expression tag |
His 1348 | - | expression tag |
His 1349 | - | expression tag |
Ser 1350 | - | expression tag |
Ala 1351 | - | expression tag |
Trp 1352 | - | expression tag |
Ser 1353 | - | expression tag |
His 1354 | - | expression tag |
Pro 1355 | - | expression tag |
Gln 1356 | - | expression tag |
Phe 1357 | - | expression tag |
Glu 1358 | - | expression tag |
Lys 1359 | - | expression tag |
Gly 1360 | - | expression tag |
Gly 1361 | - | expression tag |
Gly 1362 | - | expression tag |
Ser 1363 | - | expression tag |
Gly 1364 | - | expression tag |
Gly 1365 | - | expression tag |
Gly 1366 | - | expression tag |
Gly 1367 | - | expression tag |
Ser 1368 | - | expression tag |
Gly 1369 | - | expression tag |
Gly 1370 | - | expression tag |
Ser 1371 | - | expression tag |
Ala 1372 | - | expression tag |
Trp 1373 | - | expression tag |
Ser 1374 | - | expression tag |
His 1375 | - | expression tag |
Pro 1376 | - | expression tag |
Gln 1377 | - | expression tag |
Phe 1378 | - | expression tag |
Glu 1379 | - | expression tag |
Lys 1380 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 488479.4 | |
All* | Total formula weight | 488479.4 |